Results 91 to 100 of about 1,366,924 (271)

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Pneumocystis Infection in Pregnant Women: A Scoping Review

Journal of Fungi
Pneumocystis jirovecii is an opportunistic fungus that causes severe pneumonia in immunosuppressed individuals. While Pneumocystis colonization, a subclinical form of infection, has been studied in different populations, its implications during pregnancy
Irene Calderón-Baturone, Rocío Salsoso, Elena Charpentier, Yaxsier de Armas, Pilar Guadix, Rubén Morilla, Enrique J. Calderón, Vicente Friaza   +7 more
doaj   +1 more source

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

Clinical and Reproductive Outcomes After Hysteroscopic Repair of Isthmocele

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVE: The growing global prevalence of cesarean delivery has increased the incidence of long-term scar complications, among which isthmocele represents a clinically relevant yet often under-recognized entity.
Inci Oz, Ali Utku Oz
doaj   +1 more source

Hematologic dynamics during pregnancy and their association with obstetric complications: a retrospective cohort study

Abstract Objectives Pregnancy alters hematologic state as measured by complete blood counts (CBC), but the longitudinal changes in CBC indices that define healthy pregnancies are not well established.
Veronica Tozzo, Rachel Petherbridge, Kaitlyn James, Sarah Hsu, Chloe Michalopoulos, Brody H. Foy, Tanayott Thaweethai, Christopher Mow, Jacqueline Maya, Carolina Batlle Camero, Lydia Shook, Kathryn J. Gray, Logan Mauney, John M. Higgins, Camille E. Powe   +14 more
openaire   +2 more sources

Recurrence of Preeclampsia in Northern Tanzania: A Registry-based Cohort Study. [PDF]

, 2013
Preeclampsia occurs in about 4 per cent of pregnancies worldwide, and may have particularly serious consequences for women in Africa. Studies in western countries have shown that women with preeclampsia in one pregnancy have a substantially increased ...
Lie Rolv T., Obure, Joseph, Obure Joseph, Joseph Obure, Mmbaga, Blandina T, Lie, Rolv T, Mahande Michael J., Masenga Gileard, Masenga, Gileard, Daltveit, Anne K, Mmbaga, Blandina Theophil, Daltveit Anne K., Blandina T Mmbaga, Manongi, Rachel, Manongi Rachel, Rachel Manongi, Lie, Rolv T., Michael J Mahande, Gileard Masenga, Manongi, Rachael, Mahande, Michael Johnson, Anne K Daltveit, Mahande, Michael J, Mmbaga, Blandina T., Daltveit, Anne Kjersti, Rolv T Lie, Mmbaga Blandina T., Lie, Rolv Terje   +27 more
core   +2 more sources

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Clinical Diagnosis and Management of Pregnancy Complications

This reprint focuses on emerging trials related to pregnancy complications, including new diagnostic approaches for hypertensive disorders, gestational diabetes thresholds, and innovative management strategies for preterm birth and fetal growth ...

core   +1 more source

Undernutrition during Pregnancy [PDF]

, 2019
Evidence shows that women with undernutrition before and during pregnancy have increased risk of metabolic disorders (i.e., gestational diabetes mellitus) and are at increased risk of complications during labor and birth.
Hoang Anh Nguyen, Nguyen, Anh Hoang
core   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source