Results 91 to 100 of about 1,753,767 (304)
SAV1 in Cooperation With FKBP52 Participates in Implantation
Advanced Science, EarlyView.The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan +10 morewiley +1 more sourceCHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs
Advanced Science, EarlyView.In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu +16 morewiley +1 more sourceMaternal complications in diabetic pregnancy
Pregnant women with diabetes have to manage both the effect of pregnancy on glucose control and its effect on pre-existing diabetic complications. Most women experience hypoglycaemia as a consequence of tightened glycaemic control and this impacts on ...Hawthorne Gcore +5 more sourcesStudy protocol: differential effects of diet and physical activity based interventions in pregnancy on maternal and fetal outcomes--individual patient data (IPD) meta-analysis and health economic evaluation. [PDF]
, 2014 © 2014 Ruifrok et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...Kerry, S., Mol, BW, Mol, Ben W, Owens, Julie,, Ruifrok, A., Surita, Fernanda, de Groot, Christianne J M,, Salvesen, Kjell Åsmund,, Cecatti J. G., Renault, K, Khoury, J, van Poppel M., Sagedal, Linda Reme, Petrella, Elisabetta, Yeo, S, Renault K., van Poppel, Mireille N M, Coomarasamy, A, Haakstad, Lene, van Poppel, Mireille N.M., Ruifrok, AE, Haakstad, L, Riley, Richard D,, Khoury J., McAuliffe F. M., Phelan S., Renault, Kristina,, Rogozinska, E, Thangaratinam, S., Bogaerts, Annick, Vesco K., Rayanagoudar, Girish, null null, Van Poppel, M., Mol, B., Scudeller, Tânia T, Riley, Richard D., Vesco, K, Mol, Ben-Willem, Vitolo, Marcia, Bogaerts A., Stafne S. N., Arri Coomarasamy, Thangaratinam S., Haakstad L., Poston, L., Khoury, Janette, Kerry, S, Carballo, Ruben Barakat, Thangaratinam, Shakila,, Vitolo.,, Khalid Khan, Bogaerts, A., Poston, Lucilla; id_orcid, El Beltagy, Nermeen,, Astrup A., Devlieger, R, Rayanagoudar, G., Motahari, Narges, Sagedal, LR, Teede, Helena, Riley R. D., de Groot, Christianne J M, Shub, Alexis,, Cecatti, Jose G., Rauh, Kathrin,, Cecatti, Jose G,, Sally Kerry, Dodd, Jodie, Vistad, Ingvild,, Surita, Fernanda,, Khan, Khalid S., Rayanagoudar G., Luoto, Riitta, Yeo, SA, Thangaratinam, Shakila, Roberts T., Ewelina Rogozinska, Haakstad, Lene,, Coomarasamy, Arri, Lopez, Beth, Coomarasamy, Arri,, McAuliffe, FM, Vinter C., Hauner, Hans, de Groot, Christianne J, Luoto, Riitta,, Vitolo., Rayanagoudar, Girish,, Beltagy, NE, Vinter, Christina,, Kerry, Sally,, Barakat Carballo, Ruben,, van Poppel, Mireille N M,, Shakila Thangaratinam, Mol, Ben W., Dodd J., Morkved S., et al., Carballo R. B., McAuliffe, F., El Beltagy, Nermeen, Facchinetti, Fabio, Shen, Gary, de Groot, C., Khan K., Lucilla Poston, i-WIP (International Weight Management in Pregnancy) Collaborative Group, Luoto, R, Rogozinska, Ewelina,, van Poppel, Mireille Nm, Stafne, SN, De Groot C. J. M., De Groot, Christianne J.M., Coomarasamy, A., Khan, K, Renault, Kristina, Mol B. W., Molyneaux, E, Roberts, Tracy, Rauh K., Girish Rayanagoudar, Khan, Khalid, McAuliffe, Fionnuala, Shub, A, Ruifrok, Anneloes E., Ruifrok, Anneloes E,, Teede, Helena,, Riley, Richard D, Lopez, B, Facchinetti F., Yeo, SeonAe, Cecatti, JG, Beltagy N. E., Vistad, Ingvild, Riley, R., Coomarasamy A., Shen, Garry X,, Owens, Julie, Khan, K., Motaharim, Narges, Sagedal, Linda Reme,, Astrup, Arne,, Hauner, Hans,, Mørkved, Siv, Rauh, K, SeonAe Yeo, Christianne JM de Groot, Yeo S., Molyneaux E., Rayanagoudar, G, Cecatti, J., Vitolo, Marcia,, Rogozinska, Ewelina, Riley, Richard D; id_orcid, Prevedel T. T. S., Poston, Lucilla,, Stafne, Signe Nilssen,, Mørkved, Siv,, Cecatti, Jose G, McAuliffe, Fionnuala M, Poston L., Phelan, S, Carballo, RB, Lund University., Ruifrok A. E., Devlieger R., Phelan, Suzanne,, Yeo, Seon Ae,, Molyneaux, E., Tracy Roberts, Thangaratinam, S, Dodd, J, Roberts, Tracy,, Guelfi, K, Stafne, Signe Nilssen, Shen, Garry X, Harrison, Cheryce,, Tonstad, Serena, Carballo, R., Roberts, T., Devlieger, Roland,, Devlieger, Roland, Prevedel, Tânia T Scudeller, Guelfi, Kym,, de Groot, CJM, Emma Molyneaux, Kinnunen, Tarja I,, Fionnuala M McAuliffe, Bogaerts, A, Yeo, S., Mireille NM van Poppel, Vesco, Kimberly, van Poppel, Mireille N, Shen, G, Motaharim, N, Facchinetti, Fabio,, Geiker, Nina Rica Wium,, Kinnunen, Tarja I, Vinter, Christina, Petrella, Elisabetta,, Rogozinska E., Guelfi K., Perales, Maria,, Astrup, A, Rauh, Kathrin, Facchinetti, F, Richard D Riley, Shub A., Guelfi, Kym, Prevedel, TTS, Mørkved, S, Anneloes E Ruifrok, Salvesen, Kjell Åsmund, Yeo, Seon Ae, Shen G., Motahari, Narges,, Ruifrok, Anneloes E, Barakat Carballo, Ruben, Mol, Ben-Willem,, Dodd, Jodie,, Phelan, Suzanne, Poston, Lucilla, Luoto R., Sagedal L. R., Kerry S., Geiker, Nina Rica Wium, Vinter, C, van Poppel, Mireille, Kerry, Sally, Mol, Ben Willem, Molyneaux, Emma,, Harrison, Cheryce, Khan, Khalid S.,, McAuliffe, Fionnuala M., de Groot, Christianne Jm, Khoury, Janette,, Shub, Alexis, Motaharim N., Vinter, Christina Anne; id_orcid, Astrup, Arne, Beltagy, Nermeen El, Tonstad, Serena,, van Poppel, MNM, Ben Willem Mol, Poston, L, Molyneaux, Emma, Renault, Kristina Martha, Bogaerts, Annick,, Riley, RD, Rogozinska, E., Perales, Maria, Scudeller, Tânia T,, Roberts, T, McAuliffe, Fionnuala,, Lopez B., for the i-WIP (International Weight Management in Pregnancy) Collaborative Group +256 morecore +2 more sourcesDevelopmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models
Advanced Science, EarlyView.A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh +12 morewiley +1 more sourceFactors Affecting Pregnancy Complications in Ghana [PDF]
Global Journal on Quality and Safety in HealthcareIntroduction
The prevalence of maternal mortality continues to be a significant health concern across the world. In Ghana, pregnancy-related complications in the previous 5 years account for 12% of all deaths among women 15 to 49 years. More than half of Yaw K. Wiafe, Andrews Asamoah, Patricia Akweongo, Augustine Kumah +3 moredoaj +1 more sourceLAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury
Advanced Science, EarlyView.LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang +12 morewiley +1 more sourceStructural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance
Advanced Science, EarlyView.COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen +12 morewiley +1 more sourceA case report of heterotopic pregnancy following spontaneous pregnancy
The Journal of Qazvin University of Medical Sciences, 2017 Heterotopic pregnancy is a rare form of pregnancy and could accompany with maternal mortality and morbidity. Most of the cases have a history of assisted reproductive technology or other risk
factors like history of ectopic pregnancy and pelvic ...S. Hosseini, L. Nazari, M.Yaghmaeidoaj
