Results 51 to 60 of about 572,662 (310)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Monocyte/HDL-cholesterol ratio as an early prognostic marker of pregnancy complications development [PDF]

Arhiv za farmaciju
Pregnancy complications increase the long-term cardiovascular risk for both the mother and the child. Inflammation is a common mechanism underlying the development of pregnancy complications and atherosclerosis. This study aims to investigate whether the
Vulić Jovana, Radojković Jelena, Vekić Jelena, Stefanović Aleksandra, Ardalić Daniela, Miković Željko, Gojković Tamara, Munjas Jelena, Zeljković Aleksandra   +8 more
doaj   +1 more source

Pregnancy complications in last pregnancy and mothers’ long-term cardiovascular mortality: does the relation differ from that of complications in first pregnancy? A population-based study

BMC Women's Health, 2023
Background Women who experience complications in first pregnancy are at increased risk of cardiovascular disease (CVD) later in life. Little corresponding knowledge is available for complications in later pregnancies. Therefore, we assessed complications
Abdu Kedir Seid, Nils-Halvdan Morken, Kari Klungsøyr, Liv Grimstvedt Kvalvik, Linn Marie Sorbye, Lars Johan Vatten, Rolv Skjærven   +6 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Patient Satisfaction and Ultrasound Use During Pregnancy [PDF]

, 2014
Use, number, and frequency of ultrasounds women receive during pregnancy vary widely in practice. Current evidence suggests that women presenting with pregnancy complications benefit from additional ultrasounds, although excessive ultrasound use in low ...
McGrath, Robert J., Ricci, Paige, Stransky, Michelle   +2 more
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Spontaneous Unruptured Bilateral Tubal Pregnancy: A Case Report

Iranian Journal of Medical Sciences, 2015
Bilateral spontaneous tubal ectopic pregnancy is the rarest form of extra uterine pregnancy. The diagnosis is usually made intraoperatively and levels of serum BHCG and ultrasound has not been useful in the diagnosis of bilateral tubal ectopic pregnancy.
Nayereh Ghomian, Marziyeh Lotfalizadeh
doaj  

The Pregnancy Project: Impact of Ultrasound Use During Pregnancy Care [PDF]

, 2012
Use of ultrasounds during pregnancy continues to increase and there is much debate as to what the best practice is regarding their use, for what types of patients, at what volume level.
Ricci, Paige
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Effectiveness of Community Based Safe Motherhood Promoters in Improving the Utilization of Obstetric care. The Case of Mtwara Rural District in Tanzania. [PDF]

, 2010
In Tanzania, maternal mortality ratio remains unacceptably high at 578/100,000 live births. Despite a high coverage of antenatal care (96%), only 44% of deliveries take place within the formal health services.
Declare Mushi, Rose Mpembeni, Albrecht Jahn, UNICEF, ICM/FIGO, UN, National Bureau of Statistics, SN Massawe, F Font, National Bureau of Statistics {Tanzania} & Macro International Inc. 1997, E Urassa, KM Moore, S Thaddeus, RS Ross, M Kowalewski, M Rosato, J Elder, A Kleinman, MotherCare Matters, E Murray, C Santarelli, WHO, SB Rifkin, T Lankester, B Nwakoby, JS Kiwanuka, United Nation., A Jahn, D Mushi, J Lennon, D Werner, Tanzania Ministry of Health, District Medical Officer, E Essien, U Lehmann, HB Kendah, BN Nwakoby, S Jessop, S Rowland, B Kunene, BC Mullany, District Medical Officer, G Walraven, M Thorogood   +43 more
core   +3 more sources