Results 51 to 60 of about 347,249 (314)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Soluble Flt-1 and PlGF: new markers of early pregnancy loss? [PDF]

, 2011
Recent data have indicated a relationship between placental oxygen and angiogenic protein levels in the first trimester of normal pregnancies. Our objective was to investigate if maternal serum levels of angiogenic factors Soluble vascular endothelial ...
Michelle Swer, Muttukrishna, S, Suri, S, Jurkovic, Davor, Jamil, Amna, Swer, Michelle, Suri, Sangeeta, Sangeeta Suri, Jauniaux, E, Gangooly, Subrata, Gangooly, S, Calleja-Agius, Jean, Jamil, A, Amna Jamil, Ludlow, H, Muttukrishna, Shanthi, Jurkovic, D, Helen Ludlow, Davor Jurkovic, Calleja-Agius, J, Eric Jauniaux, Subrata Gangooly, Swer, M, Jean Calleja-Agius, Jauniaux, Eric R.M., Ludlow, Helen, Shanthi Muttukrishna   +26 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Monocyte/HDL-cholesterol ratio as an early prognostic marker of pregnancy complications development [PDF]

Arhiv za farmaciju
Pregnancy complications increase the long-term cardiovascular risk for both the mother and the child. Inflammation is a common mechanism underlying the development of pregnancy complications and atherosclerosis. This study aims to investigate whether the
Vulić Jovana, Radojković Jelena, Vekić Jelena, Stefanović Aleksandra, Ardalić Daniela, Miković Željko, Gojković Tamara, Munjas Jelena, Zeljković Aleksandra   +8 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Pregnancy complications in last pregnancy and mothers’ long-term cardiovascular mortality: does the relation differ from that of complications in first pregnancy? A population-based study

BMC Women's Health, 2023
Background Women who experience complications in first pregnancy are at increased risk of cardiovascular disease (CVD) later in life. Little corresponding knowledge is available for complications in later pregnancies. Therefore, we assessed complications
Abdu Kedir Seid, Nils-Halvdan Morken, Kari Klungsøyr, Liv Grimstvedt Kvalvik, Linn Marie Sorbye, Lars Johan Vatten, Rolv Skjærven   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Spontaneous Unruptured Bilateral Tubal Pregnancy: A Case Report

Iranian Journal of Medical Sciences, 2015
Bilateral spontaneous tubal ectopic pregnancy is the rarest form of extra uterine pregnancy. The diagnosis is usually made intraoperatively and levels of serum BHCG and ultrasound has not been useful in the diagnosis of bilateral tubal ectopic pregnancy.
Nayereh Ghomian, Marziyeh Lotfalizadeh
doaj  

Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies [PDF]

, 2012
Prolongation of pregnancy i.e. going more than 10 days over the estimated due date, complicates up to 10% of all pregnancies and is associated with increased risk to both mother and fetus.
Arrowsmith Sarah, Theodor Burdyga, Sarah Arrowsmith, Siobhan Quenby, Wray Susan, Wray, Susan, Weeks Andrew, Weeks, Andrew, Quenby, Siobhan, Arrowsmith, Sarah, Susan Wray, Quenby Siobhan, Burdyga, Theodor, Andrew Weeks, Burdyga Theodor   +14 more
core   +1 more source

Second-generation antipsychotics and pregnancy complications [PDF]

, 2020
Purpose To study if second-generation antipsychotic (S-GA) use during pregnancy is associated with an increased risk of pregnancy and neonatal complications.
Lahesmaa-Korpinen, A-M, Leinonen, Maarit K., Saastamoinen, L, Lahesmaa-Korpinen, Anna-Maria, Malm, Heli, Gissler, M,, Leinonen, MK, Elfolk, M, Nurminen, Marja-Leena, Malm, H, Saastamoinen, Leena, Nurminen, M-L, Gissler, Mika, Ellfolk, Maria   +13 more
core   +1 more source