Results 81 to 90 of about 4,625,362 (300)

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Association between plasma fluoride levels and pregnancy complications in women living in the rural and urban areas of Settat-Morocco

Gülhane Tıp Dergisi, 2023
Aims:This study aimed to investigate the relationship between plasma fluoride levels and pregnancy complications among rural and urban women living in the Settat province of Morocco, where fluorosis is endemic.Methods:This cross-sectional study included ...
Lalla Asmaa Katir Masnaoui, Fatine Hadrya, Abdellatif Rahim, Bouchra El Amiri, Boubker Nasser, Abdelkhalid Essamadi   +5 more
doaj   +1 more source

Study of the role of L-arginine in the diagnosis of pregnancy-induced hypertension [PDF]

, 2016
Background Pregnancy-induced hypertension (PIH) is a significant health issue in pregnancy, complicating 7–10% of pregnancies. L-arginine is an important mediator of vasodilation with a potential preventative role in pregnancy-related hypertensive ...
Stasiak-Kosarzycka, Marzena; Department of Gynaecology and Obstetrics with Admission Room of the Cardinal Wyszyński Regional Specialist Hospital in Lublin, Poland, Grafka, Agnieszka; I Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Poland, Karwasik-Kajszczarek, Katarzyna; Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland, Miturski, Andrzej; Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland, Łopucki, Maciej; I Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Poland, Dzida, Grzegorz; Department of Internal Diseases, Medical University of Lublin, Poland   +5 more
core   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Thrombocytopenia in Pregnancy Induced Hypertension

Journal of Medical Sciences and Health, 2015
Background: Pregnancy induced hypertension (PIH) is one of the most common causes of both maternal and neonatal morbidity. A variety of hematological abnormalities may occur in women with PIH of which thrombocytopenia is the most common.
Feroza Sultana, Raja Parthiban, Shameem Shariff   +2 more
doaj  

Hypertensive disorders of pregnancy: a systematic review of international clinical practice guidelines. [PDF]

, 2014
BACKGROUND: Clinical practice guidelines (CPGs) are developed to assist health care providers in decision-making. We systematically reviewed existing CPGs on the HDPs (hypertensive disorders of pregnancy) to inform clinical practice.
Pels, A, Anouk Pels (667541), Tessa E. R. Gillon (667540), Magee, Laura A., Laura A. Magee (512185), Anouk Pels, Magee Laura A., Tessa E R Gillon, Gillon Tessa E. R., Peter von Dadelszen, MacDonell, K, Pels Anouk, von Dadelszen, P, Gillon, Tessa E. R., Gillon, TE, Pels, Anouk, von Dadelszen, Peter; id_orcid, Karen MacDonell, Karen MacDonell (667542), MacDonell Karen, MacDonell, Karen, Peter von Dadelszen (258508), von Dadelszen Peter, Magee, LA, Laura A Magee   +24 more
core   +1 more source

Prevalence of pregnancy and birth outcomes following biologic exposure in immune‐mediated inflammatory diseases: A population‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman, Lisiane F. Leal, Gabra Nohmie, Anick Bérard   +3 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Diagnostic Agreement and Threshold Correspondence Between Resting Full‐Cycle Ratio and Nicorandil‐Based Fractional Flow Reserve in Intermediate Coronary Stenosis: A Prospective Single‐Center Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background RFR has shown good aggregate agreement with FFR, including in prior Asian cohorts using intracoronary nicorandil. Where RFR‐FFR disagreement is concentrated relative to the FFR 0.80 decision boundary, and how the two binary thresholds correspond, remain incompletely characterized. Methods In a prospective single‐center registry, 300
Yonghoon Shin, Onyou Kim, Gi Won Yu, Yun Won Lee, Jung‐Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu   +8 more
wiley   +1 more source

Crisis pregnancy and pregnancy decision making: An outline of influencing factors [PDF]

, 2004
This document aims to review research literature in order to: • outline and describe the factors that have been demonstrated to affect the level and incidence of crisis pregnancy • examine the factors that affect a woman’s decision when faced with a ...
O’Keeffe, Stephanie
core