Results 201 to 210 of about 770,380 (355)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Vaginal microbiome and recurrent pregnancy loss. [PDF]

Infect Immun
Yuan X, Gao J, Bajinka O, Feng X.
europepmc   +1 more source

Genetic Insights Into Early Pregnancy Loss: A Case Study of Trisomy 22 and an Enlarged Yolk Sac [PDF]

Dipak Kolate, N. S. Bhattacharjee, Prashant Suryarao, Swapnali Sansare   +3 more
openalex   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Thyroid disorders and pregnancy loss: a bidirectional mendelian randomization exploration. [PDF]

BMC Pregnancy Childbirth
Chen P, Zhao W, Li Y, Jia L, Fang C, Li M.   +5 more
europepmc   +1 more source

Procedural management of early pregnancy loss in different hospital settings: a cost-consequence analysis for the USA

Ubong Silas, Sita J. Saunders, Marco Caterino, Juliane Hafermann, Rhodri Saunders, Aishat Olatunde   +5 more
openalex   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Chromosomal Abnormalities in Recurrent Pregnancy Loss at a Tertiary Care Center. [PDF]

Cureus
Sinha MB, Thakur P, Verma R.
europepmc   +1 more source

GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1/5 phosphorylation

, 2023
Yuting Zeng, Wenfang Liu, Peng‐Sheng Zheng, Shan Li   +3 more
openalex   +1 more source

Primary care in the United kingdom. [PDF]

, 2008
Majeed, Azeem, Molokhia, Mariam
core   +1 more source