Results 151 to 160 of about 389,997 (312)

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

Aluminium sulphate in water in north Cornwall and outcome of pregnancy. [PDF]

, 1991
Jean Golding, Amelia Rowland, R Greenwood, PW Lunt   +3 more
openalex   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Deep Learning‐Enhanced Hand‐Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR

Advanced Science, EarlyView.
Efficient R‐CHIP HR‐HPV Screening System: The R‐CHIP system utilizes the RPA/CRISPR method, a hand‐driven centrifugal microfluidic device, a smartphone micro‐imaging system, and the ResNet‐18 deep‐learning algorithm to simplify the sample detection process, ensure accurate results, and reduce costs.
Tao Xu, Ying Zhang, Shunji Li, Chenxi Dai, Hongguo Wei, Dongjuan Chen, Yunjun Zhao, He Liu, Deliang Li, Peng Chen, Bi‐Feng Liu, Ye Tian   +11 more
wiley   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source

Analyzing the effect of prenatal care on pregnancy outcome: a conditional approach. [PDF]

, 1992
Michael H. Malloy, Ting Chang Kao, Y. J. Lee   +2 more
openalex   +1 more source

The effects of COVID-19 on pregnancy outcome. [PDF]

Clin Med (Lond), 2023
Ahmed SG.
europepmc   +1 more source

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage

Advanced Science, EarlyView.
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang, Chang Xu, Yao‐Yao Ma, Wei‐Xuan Xue, Hao‐Yuan Wang, Lin‐Yao Fan, Chen‐Yu Zhang, Liang Li, Xiao‐Yang Zhang, Jing‐Ning Zhu, Qi‐Peng Zhang   +10 more
wiley   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source