Results 121 to 130 of about 456,066 (247)

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Role of positive glucose challenge test only versus oral glucose tolerance test in pregnancy outcome: a comparative study

, 2019
Neha Homagai, Nirajan Mainali, Sikha Rijal   +2 more
openalex   +2 more sources

A combined community- and facility-based approach to improve pregnancy outcomes in low-resource settings: a Global Network cluster randomized trial [PDF]

, 2013
Omrana Pasha, Elizabeth M. McClure, Linda L. Wright, Sarah Saleem, Shivaprasad S. Goudar, Elwyn Chomba, Archana Patel, Fabian Esamai, Ana Garcés, Fernando Althabe, Bhala Kodkany, Hillary Mabeya, Albert Manasyan, Waldemar A. Carlo, Richard J. Derman, Patricia L. Hibberd, Edward K Liechty, Nancy F. Krebs, K. Michael Hambidge, Pierre Buekens, Janet Moore, Alan H. Jobe, Marion Koso‐Thomas, Dennis Wallace, Suzanne Stalls, Robert L. Goldenberg   +25 more
openalex   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Proactive Coping in Early Pregnancy and Adverse Pregnancy Outcomes

International Journal of Women's Health
Tess EK Cersonsky,1 Audra C Fain,2 Adam K Lewkowitz,3,4 Erika F Werner,5 Emily S Miller,3,4 Melissa A Clark,4,6 Nina K Ayala3,4 1Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA ...
Cersonsky TEK, Fain AC, Lewkowitz AK, Werner EF, Miller ES, Clark MA, Ayala NK   +6 more
doaj  

Maternal postprandial blood glucose levels and its relation with the pregnancy outcomes

, 2014
Vaishali Patel, Toral Goswami, Neha Pandya, Amita K. Mevada   +3 more
openalex   +2 more sources

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

O-370 Hot ambient temperature and its impacts on Adverse Pregnancy Outcome (APO) -A Systematic Review [PDF]

, 2021
Swarna Rekha, Vidhya Venogopal, SJ Nalini, S Bhuvana, S Kanmani   +4 more
openalex   +1 more source