Results 141 to 150 of about 456,066 (247)

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

open access: yesAdvanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo   +13 more
wiley   +1 more source

Carbon monoxide levels, smoking and adverse pregnancy outcomes. [PDF]

open access: yesActa Obstet Gynecol Scand
Galka K, Shea M, Aye CYL, Impey L.
europepmc   +1 more source

Investigating the Effects of Exposure to Waterpipe Smoke on Pregnancy Outcomes Using an Animal Model [PDF]

open access: bronze, 2015
Omar F. Khabour   +4 more
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

open access: yesAdvanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye   +7 more
wiley   +1 more source

Pregnancy Outcomes With and Without Adenomyomectomy in Infertile Patients With Adenomyosis: A Single-Center Retrospective Study. [PDF]

open access: yesJ Obstet Gynaecol Res
Hamaguchi F   +8 more
europepmc   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

open access: yesAdvanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong   +19 more
wiley   +1 more source

Adverse pregnancy outcomes and complications of tuberculosis in pregnant women. [PDF]

open access: yesFront Cell Infect Microbiol
Su Y, Kong X, Chen Z, Wang X, Lu S.
europepmc   +1 more source

Modeling Control of Invasive Fire Ants by Gene Drive

open access: yesAdvanced Science, EarlyView.
The fire ant Solenopsis invicta is characterized by exceptional invasive capabilities, rendering conventional control ineffective. Here, we explore the use of homing suppression gene drive in fire ants by developing a spatially explicit model. Overall, these results show that target population suppression requires an extended time scale, but that gene ...
Yiran Liu   +3 more
wiley   +1 more source

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