Results 181 to 190 of about 455,628 (245)

Anthelmintic medication with focus on first-trimester exposure: an evaluation of pregnancy outcomes based on the Embryotox cohort. [PDF]

Sci Rep
Heineke L, Beck E, Kreutz R, Dathe K.
europepmc   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Adverse Pregnancy Outcomes and Cardiovascular Health Among Offspring in Early Adulthood.

JAMA Netw Open
Lam EL, Gauen AM, Khan SS, Freedman A, Stein JH, Venkatesh KK, Tawa E, Savas H, Goldman N, Notterman DA, Lloyd-Jones DM, Allen NB, Shah NS.   +12 more
europepmc   +1 more source

Reported Pregnancy Outcomes after Biologic Therapy Exposure in Hidradenitis Suppurativa: A Systematic Review of Published Cases. [PDF]

Acta Derm Venereol
Sánchez-García V, De-Miguel-Balsa E, Ramos-Rincón JM, Belinchón-Romero I.   +3 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Impact of Work-Related Stressors on Pregnancy Outcomes of Cardiologists and Cardiovascular Team Members: It Is Complicated. [PDF]

JACC Adv
Oliveros E, Scott NS, Sharma J, Miki K, Rzeszut A, Sha S, Thakkar AB, Lundberg G, Cho L, Price A, Kurrelmeyer K.   +10 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Association Between Fetal Nuchal Translucency Measurements and Pregnancy Outcomes. [PDF]

Int J Womens Health
Zhao XN, Chang J, Sun HG, Meng H, Yao Y, Deng C, Gu YJ.   +6 more
europepmc   +1 more source