Results 21 to 30 of about 456,066 (247)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Systematic review and meta-analysis of COVID-19 maternal and neonatal clinical features and pregnancy outcomes up to June 3, 2021AJOG Global Reports at a Glance

AJOG Global Reports, 2022
OBJECTIVE: COVID-19 is a rapidly changing and developing emergency that requires constant re-evaluation of available data. We report a systematic review and meta-analysis based on all published high-quality data up to and including June 3, 2021 on the ...
Greg Marchand, MD, FACS, FICS, FACOG, Avinash S. Patil, MD, FACOG, Ahmed T. Masoud, MD, Kelly Ware, BS, Alexa King, BS, Stacy Ruther, BS, Giovanna Brazil, BS, Nicolas Calteux, BS, Hollie Ulibarri, BS, Julia Parise, BS, Amanda Arroyo, BS, Catherine Coriell, BS, Chelsea Cook, BS, Alexandra Ruuska, BS, Anas Zakarya Nourelden, MD, Katelyn Sainz, MD   +15 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Maternal and neonatal outcomes of congenital syphilis at a tertiary care center in Turkey; a retrospective observational study

Journal of Obstetrics and Gynaecology
Background Maternal syphilis (MS) can lead to significant maternal morbidity and neonatal morbidity and mortality if inadequately treated. This study is aimed to retrospectively analyse the maternal and neonatal outcomes of pregnant women diagnosed with ...
Hasan Berkan Sayal, And Yavuz, Busra Tsakir, Erzat Toprak, Orkun Han, Hasan Ali Inal   +5 more
doaj   +1 more source

Chlamydia trachomatis Screening and Treatment in Pregnancy to Reduce Adverse Pregnancy and Neonatal Outcomes: A Review

Frontiers in Public Health, 2021
Chlamydial trachomatis infection has been associated with adverse pregnancy and neonatal outcomes such as premature rupture of membranes, preterm birth, low birth weight, conjunctivitis, and pneumonia in infants. This review evaluates existing literature
Kristina N. Adachi, Karin Nielsen-Saines, Jeffrey D. Klausner   +2 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Maternal Asthma, Pregnancy, Delivery and Birth Outcomes: A Retrospective Cohort Study

Iranian Journal of Allergy, Asthma and Immunology, 2017
The aim of current study was to determine women´s maternal asthma in pregnancy, delivery and birth outcomes. Using a retrospective cohort design, data of 580 pregnant women were gathered form a large teaching hospital in Tehran, Iran. The medical records
Atefeh Vaezi, Ladan Haghighi, Farzaneh Beigmohammadi, Marzieh Nojomi   +3 more
doaj  

Drug related adverse pregnancy outcomes at a tertiary care hospital from the foothills of Himalayas: A Prospective observational study

Journal of Family Medicine and Primary Care, 2021
Context and Aim: Safety of drug usage during pregnancy is of utmost importance. Unrestricted usage of drugs may lead to undesirable and unpredictable pregnancy outcomes.
Chahat Choudhary, Arkapal Bandyopadhyay, Anupama Bahadur, Jaya Chaturvedi, Shailendra Handu, Puneet Dhamija   +5 more
doaj   +1 more source

Breast Cancer and Aging: Understanding the Complex Relationship and Implications for Prevention and Screening

Aging and Cancer, EarlyView.
ABSTRACT Background Breast cancer is a multifactorial disease that affects many women worldwide. Age is the most important risk factor for breast cancer, with an increased incidence markedly after the age of 50. The relationships of aging to breast cancer have been thoroughly examined, and notable connections regarding various age‐related changes in ...
Mehran Radak, Armin Sharifi, Derek Richard, Hossein Fallahi   +3 more
wiley   +1 more source