Results 51 to 60 of about 6,457,257 (341)

Insulin sensitivity, β cell function, and adverse pregnancy outcomes in women with gestational diabetes

Chinese Medical Journal, 2022
. Background:. The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain.
Yun Shen, Yanwei Zheng, Yingying Su, Susu Jiang, Xiaojing Ma, Jiangshan Hu, Changbin Li, Yajuan Huang, Yincheng Teng, Yuqian Bao, Minfang Tao, Jian Zhou, Lishao Guo   +12 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Chlamydia trachomatis Screening and Treatment in Pregnancy to Reduce Adverse Pregnancy and Neonatal Outcomes: A Review

Frontiers in Public Health, 2021
Chlamydial trachomatis infection has been associated with adverse pregnancy and neonatal outcomes such as premature rupture of membranes, preterm birth, low birth weight, conjunctivitis, and pneumonia in infants. This review evaluates existing literature
Kristina N. Adachi, Karin Nielsen-Saines, Jeffrey D. Klausner   +2 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Systematic review and meta-analysis of COVID-19 maternal and neonatal clinical features and pregnancy outcomes up to June 3, 2021AJOG Global Reports at a Glance

AJOG Global Reports, 2022
OBJECTIVE: COVID-19 is a rapidly changing and developing emergency that requires constant re-evaluation of available data. We report a systematic review and meta-analysis based on all published high-quality data up to and including June 3, 2021 on the ...
Greg Marchand, MD, FACS, FICS, FACOG, Avinash S. Patil, MD, FACOG, Ahmed T. Masoud, MD, Kelly Ware, BS, Alexa King, BS, Stacy Ruther, BS, Giovanna Brazil, BS, Nicolas Calteux, BS, Hollie Ulibarri, BS, Julia Parise, BS, Amanda Arroyo, BS, Catherine Coriell, BS, Chelsea Cook, BS, Alexandra Ruuska, BS, Anas Zakarya Nourelden, MD, Katelyn Sainz, MD   +15 more
doaj   +1 more source

Association of Adverse Pregnancy Outcomes With Hypertension 2 to 7 Years Postpartum

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Identifying pregnancy‐associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention.
David M. Haas, C. Parker, Derek J. Marsh, W. Grobman, Deborah B. Ehrenthal, P. Greenland, C. B. Bairey Merz, Victoria L. Pemberton, Robert M. Silver, Shannon E. Barnes, R. McNeil, K. Cleary, Uma M. Reddy, J. Chung, S. Parry, Lauren H. Theilen, Elizabeth A. Blumenthal, L. Levine, Brian M. Mercer, H. Simhan, LuAnn A. Polito, R. Wapner, J. Catov, Ida Chen, G. Saade   +24 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Maternal Asthma, Pregnancy, Delivery and Birth Outcomes: A Retrospective Cohort Study

Iranian Journal of Allergy, Asthma and Immunology, 2017
The aim of current study was to determine women´s maternal asthma in pregnancy, delivery and birth outcomes. Using a retrospective cohort design, data of 580 pregnant women were gathered form a large teaching hospital in Tehran, Iran. The medical records
Atefeh Vaezi, Ladan Haghighi, Farzaneh Beigmohammadi, Marzieh Nojomi   +3 more
doaj  

Clinical features at the time of non-hysteroscopic myomectomy before pregnancy, which affect adverse pregnancy outcomes: a retrospective cohort study [PDF]

, 2022
Young Ran Kim, Eun Duc Na, Jae Eun Jung, Ji Hyun Moon, Ji Yeon Lee   +4 more
openalex   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source