Results 61 to 70 of about 1,093,029 (362)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Desempenho reprodutivo de fêmeas suínas inseminadas pela técnica intra-uterina ou tradicional Reproductive performance of swine females inseminated by intrauterine or traditional technique

Pesquisa Agropecuária Brasileira, 2004
O desempenho reprodutivo de fêmeas suínas foi avaliado com o objetivo de comparar duas técnicas de inseminação. Foram inseminadas, em delineamento inteiramente casualizado, 608 fêmeas com ordem de parto de dois a quatro, em dois tratamentos: inseminação ...
Djane Dallanora, Alisson Mezalira, Lia Helena Katzer, Mari Lourdes Bernardi, Fernando Pandolfo Bortolozzo, Ivo Wentz   +5 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Application of platelet-rich plasma in assisted reproductive technology

Zhongguo shuxue zazhi
Assisted reproductive technology(ART) faces challenges such as low embryo implantation rates due to uterine factors, and infertility caused by ovarian function suppression and abnormal semen.
Ling WU, Qiang TAN, Tao PENG, Xinyu GAN
doaj   +1 more source

Previous reproductive history and post-natal family planning among HIV-infected women in Ukraine [PDF]

, 2010
BACKGROUND: Ukraine has the highest antenatal HIV prevalence in Europe. The national prevention of mother-to-child transmission (MTCT) programme has reduced the MTCT rate, but less attention has been given to the prevention of unintended pregnancy among ...
Boily, C. Thorne, Campbell, Corey, Delvaux, E. Kulakovskaya, Floridia, Gottlieb, Heard, I. Adejnova, I. Semenenko, J. Saxton, Kruglov, L. Kvasha, Mogilevkina, Mogilevkina, Mwapasa, Ostergren, Perlman, Popov, R. Malyuta, R. Tereshenko, Radestad, Rutenberg, Sanders, Sheth, Stanwood, Stringer, T. Pilipenko, Thorne, Thorne, van Brummen, Vikhlyaeva   +32 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Study of Tubal Recanalization in Era of ART (Assisted Reproduction Technology) [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Tubectomy remains one of the most popular methods of permanent contraception in developing countries. But about 10% of them regret their decision and 1% want to restore their fertility.
Sowmya Koteshwar, Anjali Siddesh
doaj   +1 more source

Coital rate and pregnancy-induced hypertension [PDF]

Human Reproduction, 1997
Previous workers have emphasized the possibility that pregnancy-induced hypertension (PIH) is associated with a change of sexual partner. It is noted here that any such association is far weaker than that between PIH and fecundability (the probability of conceiving in a month at risk). This latter association is so strong as to suggest its closeness to
openaire   +2 more sources

U.S. Teenage Pregnancies, Births, and Abortions, 2010: National and State Trends by Age, Race, and Ethnicity [PDF]

, 2014
This report contains the most recent and comprehensive statistics available -- for 2010 -- on the incidence of teenage pregnancy, birth and abortion for the United States as a whole and for individual states.
Kathryn Kost, Stanley Henshaw
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source