Results 181 to 190 of about 367,487 (260)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Compartmentalized and Differential Regulation of NK- and γδ T-Cell Degranulation by Trophoblast-Derived Signals During Early Pregnancy. [PDF]

Cells
Ivanova M, Alexandrova M, Parvanov D, Manchorova D, Terzieva A, Vangelov I, Kirilov K, Dimova T.   +7 more
europepmc   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Glycated CD59: a novel biomarker for gestational diabetes.

Endocr Rev
Toth Castillo M, Drayton Powell S, Biermann A, Torrey J, Luque-Fernandez MA, Halperin J.   +5 more
europepmc   +1 more source

Awareness, Preferences, and Willingness to Download Pregnancy Health Management Apps Among Women in Louisiana: Cross-Sectional Survey. [PDF]

JMIR Form Res
Chaudhary P, Bourgeois A, Underwood R, Martin M, Denstel K, Redman L, Staiano A.   +6 more
europepmc   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Diet Diversity Is Associated with Prepregnancy Body Mass Index but Not the Pregnancy Third-Trimester Gut Microbiota. [PDF]

Curr Dev Nutr
Sheth HJ, Xie SY, Kerver JM, Comstock SS.   +3 more
europepmc   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Infant, maternal and pregnancy associated risk factors for offspring fractures during infancy - A population-based study. [PDF]

Child Abuse Negl
Derauf C, Rao R, King K, Hentz R, Potter DD, Katz AR, Melville J.   +6 more
europepmc   +1 more source