Results 81 to 90 of about 13,833,785 (313)

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Trilostane as antiprogestin therapy in pregnancy termination [PDF]

, 2000
Includes bibliographical ...
Zinn, Philip M
core   +1 more source

Irish contraception and crisis pregnancy [ICCP] study: a survey of the general population - summary [PDF]

, 2004
The aim of the present study was to establish nationally representative data on current attitudes, knowledge and experience of contraception, crisis pregnancy and related services in Ireland.
McGee, Hannah, Leigh, Collette, Rundle, Kay, Layte, Richard   +3 more
core  

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]

, 2014
STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
Whitley, G S, Goulwara, S S, Johnstone, A P, Cartwright, JE, Whitley, GS, Goulwara, SS, Cartwright, J E, Wallace, A E, Fraser, R, Gurung, S, Wallace, AE, Johnstone, AP   +11 more
core   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

First-trimester diet quality in association with maternal subcutaneous and visceral adipose tissue thicknesses and glucose homeostasis during pregnancy

, 2023
We aimed to characterise the associations between first-trimester diet quality, adiposity, and glucose homeostasis measurements throughout pregnancy in a sample of 104 healthy pregnant women.
Anne-Sophie Morisset (5132495), Julie Robitaille (796418), S. John Weisnagel (8102691), Claudia Gagnon (642022), Anne-Sophie Plante (8411373), Mario Girard (3015435), Emmanuel Bujold (796420), Simone Lemieux (3188934), André Tchernof (541752), Emilie Bernier (14519807)   +9 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Patterns of anti-malarial drug treatment among pregnant women in Uganda. [PDF]

, 2011
BACKGROUND: Prompt use of an effective anti-malarial drug is essential for controlling malaria and its adverse effects in pregnancy. The World Health Organization recommends an artemisinin-based combination therapy as the first-line treatment of ...
Staedke Sarah G, Sarah G Staedke, Brentlinger Paula E, Andy Stergachis, Paula E Brentlinger, Stergachis, Andy, Laura R Sangaré, Richardson, Barbra A, Staedke, Sarah G, Weiss Noel S, Barbra A Richardson, Weiss, Noel S, Stergachis Andy, Mpungu S Kiwuwa, Kiwuwa, Mpungu S, Sangaré Laura R, Brentlinger, Paula E, Kiwuwa Mpungu S, Richardson Barbra A, Noel S Weiss, Sangaré, Laura R   +20 more
core   +1 more source

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source

Association between Antibiotic Prescribing in Pregnancy and Cerebral Palsy or Epilepsy in Children Born at Term: A Cohort Study Using The Health Improvement Network. [PDF]

, 2015
Between 19%-44% pregnant women are prescribed antibiotics during pregnancy. A single, large randomised-controlled-trial (ORACLE Childhood Study II) found an increased risk of childhood cerebral palsy and possibly epilepsy following prophylactic ...
Wilhelmine Hadler Meeraus (711413), Ruth Gilbert (122786), Wilhelmine Hadler Meeraus, Petersen, I, Gilbert, R, Irene Petersen, Meeraus, WH, Ruth Gilbert, Irene Petersen (286674)   +8 more
core   +1 more source