Results 81 to 90 of about 200,786 (315)

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Assessing the psychological impact and acceptability of a first-trimester screening test for pre-eclampsia

, 2015
BACKGROUND: A first-trimester prenatal screening test for pre-eclampsia was launched in 2010. It differs from previously assessed prenatal screening tests.
Harris, JM
core  

Partial molar pregnancy with live fetus diagnosed on second trimester: a case report [PDF]

, 2016
Hydatidiform mole is part of a group of diseases classified as gestational trophoblastic disease, which results from an aberrant fertilization. They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a ...
Santos, Angela, Cardoso, Rosete Maria Amorim Novais Nogueira, Gama, Ana Paula, Pinheiro, Paula, Trocado, Vera   +4 more
core   +1 more source

Pregnancy‐related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas, Naim Bouazza, Frantz Foissac, Saïk Urien, Léo Froelicher‐Bournaud, Gabrielle Lui, Victoria Guillemart, Nicolas Carlier, Jennifer Da Silva, Johanna Fesenbeckh, Reem Kanaan, Isabelle Honoré, Clémence Martin, Jean‐Marc Treluyer, Vassilis Tsatsaris, Pierre‐Régis Burgel, Sihem Benaboud   +16 more
wiley   +1 more source

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation

, 2009
Objectives: To determine the acceptability, efficacy and costs of medical termination of pregnancy (MTOP) compared with surgical termination of pregnancy (STOP) at less than 14 weeks’ gestation, and to understand women’s decision-making processes and ...
Kelly, T., SC Robson, T Kelly, Lie, M.L.S., Hewison, J., J Hewison, Armstrong, N ., MLS Lie, M Deverill, Howel, D., Stamp, E., CR May, Deverill, M., D Howel, E Stamp, D Howel,, May, C.R ., Robson, S.C., N Armstrong   +18 more
core   +1 more source

Safety of Amlodipine in Early Pregnancy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited. Methods and Results In the present study, we recruited 231 women with chronic hypertension, including those who received amlodipine or
Asako Mito, Atsuko Murashima, Yoshinao Wada, Mai Miyasato‐Isoda, Chizuko A. Kamiya, Masako Waguri, Jun Yoshimatsu, Naho Yakuwa, Omi Watanabe, Tomo Suzuki, Naoko Arata, Masashi Mikami, Shinya Ito   +12 more
doaj   +1 more source

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Altered placental expression of kisspeptin and its receptor in pre-eclampsia [PDF]

, 2012
Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy.
Williams, Paula Juliet, Cartwright, JE, Williams, PJ, Cartwright, Judith E.   +3 more
core   +1 more source

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

Journal of Research in Medical Sciences, 2020
Background: This study was aimed at comparing the efficacy of different routes of misoprostol administration, including sublingual, oral, and vaginal, on the induction of medical abortion in the first trimester of pregnancy.
Behnaz Souizi, Rahim Akrami, Fateme Borzoee, Mohammad Sahebkar   +3 more
doaj   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source