Results 91 to 100 of about 367,765 (333)

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Ruptured Tubal Ectopic Pregnancy at Fifteen Weeks Gestational Age

Clinical Practice and Cases in Emergency Medicine, 2019
Tubal ectopic pregnancies are commonly diagnosed during the first trimester. Here we present a second-trimester tubal ectopic pregnancy that was previously misdiagnosed as an intrauterine pregnancy on a first-trimester ultrasound. A 39-year-old gravida 1
Justine K. Stremick, Kyle Couperus, Simeon W. Ashworth   +2 more
doaj   +1 more source

The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre‐eclampsia: A pragmatic guide for first‐trimester screening and prevention

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019
Pre‐eclampsia (PE) is a multisystem disorder that typically affects 2%–5% of pregnant women and is one of the leading causes of maternal and perinatal morbidity and mortality, especially when the condition is of early onset.
L. Poon, A. Shennan, J. Hyett, A. Kapur, E. Hadar, H. Divakar, F. Mcauliffe, F. S. Silva Costa, P. Dadelszen, H. Mcintyre, A. Kihara, G. D. Di Renzo, R. Romero, M. D’Alton, V. Berghella, K. Nicolaides, M. Hod   +16 more
semanticscholar   +1 more source

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Hubungan Karakteristik Ibu Hamil Trimester III Dengan Tingkat Kecemasan Dalam Menghadapi Persalinan Di Poli Kia Puskesmas Tuminting [PDF]

, 2014
: Anxiety (Anxiety) is a fear that is not clear and is not supported by the circumstances. Pregnancy can be a source of anxiety stressor, Pregnancy classified into the first trimester, second trimester and third trimester. Anxiety experienced by pregnant
Bidjuni, H. (Hendro), K, A. W. (Asri), Kallo, V. (Vandri)   +2 more
core  

Prenatal ultrasound screening for fetal anomalies and outcomes in high-risk pregnancies due to maternal HIV infection : a retrospective study [PDF]

, 2013
Objective: To assess the prevalence of prenatal screening and of adverse outcome in high-risk pregnancies due to maternal HIV infection. Study design: The prevalence of prenatal screening in 330 pregnancies of HIV-positive women attending the ...
Buxmann, Horst, Haberl, Annette Elisabeth, Herrmann, Eva, Louwen, Frank, Reitter, Anke, Schlößer, Rolf Lambert, Stücker, Anja-Undine   +6 more
core   +2 more sources

Early‐Life Clinical Factors Shape Cerebellar Structure in Preterm‐Born Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Preterm birth alters typical brain development due to complex exposures related to neonatal illness, pain management, and brain injury. Despite an increased understanding of neonatal brain injury on developmental outcomes, the association of cerebellar maturation with school‐age motor and cognitive function remains incompletely ...
Victoria Rapos, Steven Ufkes, Cecil Chau, Jessie van Dyk, Ting Guo, Ruth E. Grunau, Steven P. Miller   +6 more
wiley   +1 more source

Fetal genetic factors in pregnancy loss: Insights from a meta-analysis and effectiveness of whole exome sequencing.

PLoS ONE
Spontaneous pregnancy loss commonly occurs during the first trimester and can be caused by various factors including chromosomal abnormalities and submicroscopic aberrations.
Andrea Hadjipanteli, Athina Theodosiou, Ioannis Papaevripidou, Angelos Alexandrou, Nicole Salameh, Paola Evangelidou, Marios Tomazou, Andreas Mavrides, Sozos Fasouliotis, George Anastasiou, Andreas Stavroulis, Niki Agathokleous, Maria Agathokleous, Stelios Tsangarides, Ioannis Kallikas, Kyriakos Kakoullis, Sofia Frakala, Christina Oxinou, Andreas Marnerides, Emilia Athanasiou, Sofia Ourani, Violetta C Anastasiadou, George Tanteles, Ludmila Kousoulidou, Carolina Sismani   +24 more
doaj   +1 more source

Raised electrical uterine activity and shortened cervical length could predict preterm delivery in a low-risk population [PDF]

, 2012
PURPOSE: To compare diagnostic accuracy of sonographic cervical length (CL) measurement and uterine electric activity assessed by electromyography (EMG) in second trimester regarding prediction of preterm delivery (PTD).
Grgić, Ozren, Kuna, Krunoslav, Matijević, Ratko   +2 more
core   +1 more source