Results 81 to 90 of about 339,710 (309)

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, EarlyView.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Uterine wall thickness at the second trimester can predict subsequent preterm delivery in pregnancies with adenomyosis

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objectives: We assessed the usefulness of ultrasonography (USG) findings of adenomyosis during pregnancy in the prediction of subsequent preterm delivery.
Yoo-Min Kim, Soo Hyun Kim, Ji-Hye Kim, Ji-Hee Sung, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh   +6 more
doaj   +1 more source

Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure – a pilot study [PDF]

, 2013
The mechanisms of obesity associated reproductive complications remain poorly understood. Endometrial mesenchymal stem-cells are critical for cyclic renewal and uterine function.
Bhandari, Harish, Brosens, Jan J., Gargett, Caroline E., Lucas, Emma S., Murakami, Keisuke, Quenby, Siobhan, Takeda, Satoru, Tan, Bee K.   +7 more
core   +2 more sources

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Maternal morbidity associated with violence and maltreatment from husbands and in-laws: findings from Indian slum communities. [PDF]

, 2016
BackgroundIntimate partner violence (IPV) victimization is linked to a broad range of negative maternal health outcomes. However, it is unclear whether IPV is directly related to poor maternal outcomes or whether IPV is a marker for other forms of ...
Balaiah, Donta, Boyce, Sabrina C, Dasgupta, Anindita, Decker, Michele R, Naik, DD, Nair, Saritha, Raj, Anita, Ritter, Julie, Saggurti, Niranjan, Silverman, Jay G   +9 more
core   +2 more sources

Pregnancy outcome following mid-trimester amniocentesis

Journal of Obstetrics and Gynaecology, 2012
To determine the institutional pregnancy complications rate associated with genetic amniocentesis and ascertain whether procedural variables or pre-existing factors may determine an increased risk of having a procedural-related fetal loss, we retrospectively evaluated all the consecutive amniocentesis, with known pregnancy outcome (n = 2990), performed
CORRADO, Francesco, Cannata ML, LA GALIA, TINDARA, MAGLIARDITI, MARIA, IMBRUGLIA, LAURA, D'ANNA, Rosario, CARLO STELLA, Narciso   +6 more
openaire   +3 more sources

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Pregnant patients undergoing cholecystectomy: nationwide assessment of clinical characteristics and outcomesAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: Gallstone disease in pregnancy is one of the most common indications for nonobstetrical surgery during pregnancy. National-level data on contemporary surgical practice and outcomes are limited.
Genevieve R. Mazza, MD, Ariane C. Youssefzadeh, MD, Laurel S. Aberle, MD, Zachary S. Anderson, MD, Rachel S. Mandelbaum, MD, Joseph G. Ouzounian, MD, MBA, Kazuhide Matsushima, MD, Koji Matsuo, MD, PhD   +7 more
doaj   +1 more source

Successful delivery after vaginal occlusion in addition to cerclage in a trachelectomy patient with recurrent second trimester pregnancy loss:a case report [PDF]

, 2014
KEY CLINICAL MESSAGE: Pregnancy outcome after trachelectomy has high risk of complications such as second trimester pregnancy loss and preterm birth.
Langhoff-Roos, Jens, Ottosen, Christian, Poulsen, Mette Østergaard, Sneider, Kirstine   +3 more
core   +2 more sources