Results 261 to 270 of about 235,181 (316)

M2042 The Role of Pregnane X Receptor (PXR/NR1i2) Gene Variants in Inflammatory Bowel Disease

, 2008
Julia Seiderer, Jürgen Glas, Julia Diegelmann, D Fischer, B. Seitz, Cornelia Tillack, Simone Pfennig, Astrid Konrad, Martin Wetzke, Thomas Griga, Wolfram Klein, Jörg T. Epplen, U Schiemann, Thomas Mussack, Peter Lohse, Burkhard Göke, Thomas Ochsenkuehn, Matthias Folwaczny, Bertram Müller‐Myhsok, Stephan Brand   +19 more
openalex   +1 more source

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation

Journal of Pharmacology and Experimental Therapeutics, 2016
Aditya Garg, Angela Zhao, Sarah L. Erickson, Subhajit Mukherjee, A. Lau, L. Alston, Thomas K. H. Chang, S. Mani, S. Hirota   +8 more
semanticscholar   +1 more source

The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Nilles J, Weiss J, Masin M, Tuffs C, Strowitzki MJ, Haefeli WE, Ruez S, Theile D.   +7 more
europepmc   +1 more source

Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration

Drug Metabolism And Disposition, 2016
Hang Zeng, Dongshun Li, Xiao-ling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang, H. Bi   +13 more
semanticscholar   +1 more source

Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier. [PDF]

Fluids Barriers CNS
Colón Ortiz R, Knerler S, Fridman LB, Mercado A, Price AS, Rosado-Franco JJ, Wilkins H, Flores BR, Orsburn BC, Williams DW.   +9 more
europepmc   +1 more source

Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database

, 2010
Sandhya Kortagere, Matthew D. Krasowski, Erica J. Reschly, Madhukumar Venkatesh, Sridhar Mani, Sean Ekins   +5 more
openalex   +1 more source

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Dietary phytochemicals as modulators of human pregnane X receptor

Critical Reviews in Food Science and Nutrition, 2021
As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this review aims to summarize the plant-derived PXR modulators, including agonists, partial agonists, and antagonists.
Petr Pavek, Jie Zhang, Rajamanikkam Kamaraj, Tiehua Zhang, Li Ren   +4 more
openaire   +3 more sources

Binding of Per- and Polyfluoroalkyl Substances to the Human Pregnane X Receptor.

Environmental Science and Technology, 2020
Per- and polyfluoroalkyl substances (PFASs) are a class of environmentally persistent industrial compounds that disrupt various metabolic pathways. Among the protein receptors to which PFASs bind, the human pregnane X receptor (hPXR) is found to be a ...
T. T. Lai, Yiğitcan Eken, A. Wilson
semanticscholar   +1 more source

Pregnane X Receptor Activation in Liver Perfusion

Transplantation Proceedings, 2022
Liver normothermic machine perfusion (NMP) is being adopted as a method of optimizing livers before transplantation. However, there is further potential to use the NMP model as a platform for drug delivery. Pregnane X receptor (PXR) activation upregulates CYP3A expression and has been shown to be protective against ischemia-reperfusion in rodents.
Samuel Moulding, Rodrigo Figueiredo, Avinash Sewpaul, Alistair Leitch, Lucy Bates, Matthew Wright, Colin Wilson   +6 more
openaire   +3 more sources

Transcriptional Regulation of the Human Pregnane-X Receptor

Drug Metabolism Reviews, 2006
This review addresses the general structure and function of nuclear receptors and places specific emphasis on their role in xenosensing, resulting in the activation of a battery of genes mediating drug metabolism, conjugation, and transport. The pregnane-X receptor is a nuclear receptor that functions to control a battery of genes predominantly ...
Gibson, GG, Phillips, A, Aouabdi, S, Plant, K, Plant, N   +4 more
openaire   +4 more sources