Results 281 to 290 of about 2,043,399 (338)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tuberculosis screening and care delivery in pregnant and postpartum persons living with HIV in Botswana. [PDF]

PLOS Glob Public Health
Dubois MM, Powell M, Schenkel S, Kgole S, Masasa G, Ngwaca M, Phale B, Diphoko A, Kgathi C, Masheto G, Makhema J, Makhondo T, Mbenge C, Sharma T, Sundararajan R, Mathad J, Modongo C, Butler LM, Fitzgerald D, Powis KM.   +19 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Results from a maternal, newborn and child health program targeting pregnant, married adolescent girls in northern Nigeria. [PDF]

PLOS Glob Public Health
Felker-Kantor E, Phillips M, Cutherell M, Odeh R, Lois S, Bulama A, Musau A.   +6 more
europepmc   +1 more source

Temporal trends in the prescription of traditional Japanese herbal (Kampo) medicines to pregnant women: analysis of an administrative hospital database in Japan. [PDF]

J Pharm Health Care Sci
Kikuchi D, Obara T, Hatakeyama S, Josaka R, Tokunaga M, Okada K, Murai Y.   +6 more
europepmc   +1 more source

Psychosocial Perceptions and Health Behaviors Related to Lifestyle During Pregnancy: A Cross-Sectional Study in a Local Community of Albania. [PDF]

Healthcare (Basel)
Durmishi S, Lalo R, Kamberi F, Hidri S, Gugu M.   +4 more
europepmc   +1 more source

Prevalence of Severe Thalassemia and Performance of Prenatal Screening Tests Among Pregnant Women at Siriraj Thalassemia Center in Thailand. [PDF]

Clin Transl Sci
Malasai K, Chaikledkaew U, Talungchit P, Youngkong S, Udomsinprasert W, Limwongse C, Jittikoon J.   +6 more
europepmc   +1 more source