Results 121 to 130 of about 4,570,167 (353)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Smoking Patterns and Receipt of Cessation Services Among Pregnant Women in Argentina and Uruguay [PDF]

, 2015
Introduction: The 5A’s (Ask, Advise, Assess, Assist, and Arrange) strategy, a best-practice approach for cessation counseling, has been widely implemented in high-income countries for pregnant women; however, no studies have evaluated implementation in ...
Alemán, Alicia, Althabe, Fernando, Becú, Ana, Belizan, Jose, Berrueta, Amanda Mabel, Buekens, Pierre, Ciganda, Alvaro, Colomar, Mercedes, Dietz, Patricia M., Farr, Sherry L., Gibbons, Luz, Johnson, Carolyn, Llambi, Laura, Mazzoni, Agustina, Morello, Paola, Smith, Ruben A., Tong, Van T.   +16 more
core   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

The prevalence of psychiatric symptoms of pregnant and non-pregnant women during the COVID-19 epidemic

Translational Psychiatry, 2020
Coronavirus disease 2019 (COVID-19) is rapidly spreading worldwide, with a staggering number of cases and deaths. However, available data on the psychological impacts of COVID-19 on pregnant women are limited.
Yongjie Zhou, Hui Shi, Zhengkui Liu, Songxu Peng, Ruoxi Wang, Ling Qi, Zezhi Li, Jiezhi Yang, Yali Ren, Xiuli Song, Lingyun Zeng, Wei Qian, Xiangyang Zhang   +12 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Fair inclusion of pregnant women in clinical trials: an integrated scientific and ethical approach

Trials, 2018
Background Since pregnant women are severely underrepresented in clinical research, many take the position that the exclusion of pregnant women from research must be justified unless there are compelling “scientific reasons” for their exclusion. However,
Rieke van der Graaf, Indira S. E. van der Zande, Hester M. den Ruijter, Martijn A. Oudijk, Johannes J. M. van Delden, Katrien Oude Rengerink, Rolf H. H. Groenwold   +6 more
doaj   +1 more source

Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China

BMC Medicine, 2020
Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes.
Rong Yang, H. Mei, T. Zheng, Q. Fu, Yi-ming Zhang, S. Buka, Xin-yi Yao, Zezhong Tang, Xichi Zhang, Lin Qiu, Yaqi Zhang, Jieqiong Zhou, Jiangxia Cao, Youjie Wang, Aifen Zhou   +14 more
semanticscholar   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Pathological pregnancy and psychological symptoms in women [Patološka trudnoća i psihički simptomi u žena] [PDF]

, 2012
Pregnancy is followed by many physiologic, organic and psychological changes and disorders, which can become more serious in pregnancy followed by complications, especially in women with pathological conditions during pregnancy. The purpose of this study
Bjelanović, Vedran, Babić, Dragan, Orešković, Slavko, Tomić, Vajdana, Martinac, Marko, Juras, Josip   +5 more
core  

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source