Results 101 to 110 of about 150,118 (311)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A study of the perceptions of race and experience of prejudice in Grade Four learners at a Cape Town primary school [PDF]

open access: yes, 2009
The researcher is a social worker at a primary school in Cape Town. This school was previously reserved for white children during the apartheid era, but now provides education for a multi-racial group of children, who are predominantly of mixed race. The
West, Verusha
core   +1 more source

Language, Prejudice, Awareness, and Resistance

open access: yesOpen Linguistics, 2020
As an introduction to the themed special volume on Language and Prejudice, this short editorial highlights aspects related to prejudice within, through, and towards language as well as how prejudice and stereotyping can affect our perception of language.
Deutschmann Mats, Steinvall Anders
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An experimental test of prejudice about foreign people [PDF]

open access: yes
This paper o¤ers two related issues: (i ) an applications of beliefs about the cooperative behavior of others to policy-oriented issues, (ii ) a method of explor- ing prejudices (toward others) where interviewees are oblivious of its purpose.
Olusegun A. Oyediran   +2 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

An analysis of prejudice and discrimination in Amrican history x (1998) film

open access: yes, 2014
This reseach studies about American History X film directed by David McKeena on 1998. The analysis is aimed to find out how prejudice and discrimination issues and the relationship between prejudice and discrimination is described through theories of ...
Muhammad Aji Akasyah   +2 more
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Social norms and prejudice: the impact of egalitarianism and competition on the automatic prejudice against blacks / Normas sociais e preconceito: o impacto da igualdade e da competição no preconceito automático contra os negros

open access: yesPsicologia: Reflexão e Crítica, 2006
The present studies examined the effects of social norms on the automatic prejudice against Black people. Study 1 assessed the effects of egalitarianism and competitive meritocracy on automatic racial prejudice.
Marcus Eugênio O. Lima   +4 more
doaj  

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

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