Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
ChatHTN: a consultation model for hypertension. [PDF]
Sci RepWang D, Yuan Z, Deng H, Peng Z.
europepmc +1 more source
Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design
Advanced Science, EarlyView.A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram +4 more
wiley +1 more source
Revise the cognitive model using structural equation modeling. [PDF]
Front PsycholLin S +5 more
europepmc +1 more source
Entropy Decoding the Fundamental Law of Phase Competition in Glass Formation
Advanced Science, EarlyView.We validate the integration of intermetallic and eutectic phases as initial phases for composition design. The phase competition mechanism in glass formation is quantitatively clarified based on the melting entropy of competing phases. Glass‐forming ability is modulated by tuning phase competition via the melting entropy of initial phases.
Benke Huo +7 more
wiley +1 more source
German translation, cultural adaptation and linguistic validation of the PedsQL healthcare satisfaction module. [PDF]
Health Qual Life OutcomesPiltz A +5 more
europepmc +1 more source
Advanced Science, EarlyView.Bulk FePd2Te2 contains sparse interlayer Pd–Te covalent bonds, giving it unexpectedly low exfoliation energy and enabling van der Waals‐like exfoliation. Cleaving these bonds during exfoliation makes the monolayer magnetically distinct from the bulk: magnetic anisotropy energy increases, and the strain‐response coefficient of the magnetic moment ...
Huaiyuan Zhao +7 more
wiley +1 more source
Mapping Practice-Based Signals of Generative AI in Psychiatric Care: Qualitative Study of Korean Psychiatrists' Experiences, Interpretations, and Implementation Priorities. [PDF]
J Med Internet ResKim M +11 more
europepmc +1 more source
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Exploring Students' Perceptions and Usage of Artificial Intelligence in Supporting Mental Health: A Preliminary Study in Higher Education in Qatar. [PDF]
Healthcare (Basel)ElBarazi AS, Mohamed H, Nasser R.
europepmc +1 more source