Results 81 to 90 of about 369,443 (259)
The Precautionary Attitude: Asking Preliminary Questions [PDF]
Hastings Center Report, 2014 AbstractInnovation in basic science is often a cause for wonder and excitement. Those associated with a new development are quick to point out the anticipated benefits: a cure for cancer or dementia, an end to unsafe water or hunger. These advocates are slower to draw attention to the possible costs, which may become known only much later.
openaire +2 more sources
White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Die menslike embrio – ’n reg op lewe? ’n Voorlopige teologies-etiese beoordeling
In die Skriflig, 2002 The human embryo – a right to life? A preliminary theological-ethical evaluation It is known that the human embryo is currently (during in-vitro impregnation/conception) qualitatively and genetically selected, after which unwanted embryos are destroyed.
A.L. Rheeder
doaj +1 more source
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
Genetiese manipulasie as selektiewe voortplanting – ’n voorlopige teologies- etiese beoordeling
In die Skriflig, 2006 Genetic manipulation as selective reproduction – a preliminary theological-ethical assessment Genetic manipulation – the technology in which genes are placed in embryos and gametes of animals – with the purpose of creating certain intended genetic ...
A. L. Rheeder, J. M. Vorster
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
La quantification universelle en trio: tous les, chaque et tout [PDF]
Studii de Lingvistica, 2011 This article revisits the well-known question of the quantification made by chaque, tout and tous les, that express totality or universal quantification, by focusing on a preliminary question: should we group the three quantifiers or not? Most frequently
Georges Kleiber
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Alexia Moukhine +40 more
wiley +1 more source