Results 151 to 160 of about 391,696 (304)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

More than words? Defining best practices in assessing surrogate understanding. [PDF]

ATS Sch
Arnold JM, Smith MM, Wood GJ, Vermylen JH, Walter JM.   +4 more
europepmc   +1 more source

Question and Answer service decentralised: PRAIS is right

, 2014
CTA has decided to decentralise its long-established question and answer (Q&A) service to a number of regional centres. Preliminary consultations are underway in the Caribbean (CARDI for Trinidad and Tobago, and Jamaica and Saint Lucia) and East..
Technical Centre for Agricultural and Rural Cooperation
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Rapid e-Delphi Design of a Survey on Student Lifestyles, Psychological, and Contextual Factors Integrating the World Mental Health International College Student Assessment in the Italian Higher Education Setting. [PDF]

Int J Methods Psychiatr Res
Mosconi G, Vigezzi GP, Franchina E, Barbati C, Barello S, Brusaferro S, Morelli I, Emdin M, Faggiano F, Gallus S, Molinaro S, Ogliari A, Pacini B, Politi P, Raglio A, Ramat S, Rizzo C, Rossi E, Vecchi T, Vigna-Taglianti F, Zingarelli M, Odone A, Health Mode On Investigators.   +22 more
europepmc   +1 more source

Preliminary questions

, 2023
openaire   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Performance of Large Language Models on the Brazilian National Medical Education Examination: Comparative Benchmark Study. [PDF]

JMIR Med Educ
Fernandes da Silva FL, Roeder EA, Bruneti Severino JV, Nespolo Berger M, Basei de Paula PA, Ferreira D, Han Veiga M, de Moraes TP, Lenci Marques G.   +8 more
europepmc   +1 more source

The impact of question type and empathy on police interviews with suspects of homicide, filicide and child sexual abuse [PDF]

, 2014
Cherryman, Julie, Morris, Paul, Oxburgh, Gavin, Ost, James   +3 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source