Results 71 to 80 of about 391,696 (304)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Is making the conclusion of contracts for the provision of broadband internet access service conditional upon the conclusion of a contract for telephone services prohibited? Case comment to the preliminary ruling of the Court of Justice of 11 March 2010 Telekomunikacja Polska SA v President of Office of Electronic Communications (Case C-522/08) [PDF]

Yearbook of Antitrust and Regulatory Studies, 2011
In its preliminary ruling delivered on 11 March 2010, the Court of Justice had yet another opportunity, after the VTB-VAB and Galatea cases, to express its views on the legality of national legislation prohibiting combined sales (that is bundling and ...
Anna Pisarkiewicz
doaj  

THE STATUS OF INTERNATIONAL AGREEMENTS CONCLUDED BY THE EUROPEAN UNION IN THE EU LEGAL ORDER

Pravni Vjesnik, 2017
The European Union is a member of the international community and is a party to numerous international agreements. The status of these international agreements in the EU legal order however is not made expressly clear by the Treaties.
Agoston Mohay
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

To the question of differentiation of the preliminary investigation

Legal Science and Practice: Journal of Nizhny Novgorod Academy of the Ministry of Internal Affairs of Russia, 2022
The author carried out a comparative analysis of such forms of preliminary investigation as preliminary investigation and inquiry, touched upon problematic issues arising in the practical activities of interrogators, suggested possible ways of their solution.
openaire   +1 more source

Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3mP Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM3P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the ...
R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F. J. de Jong, E. G. P. Dopper, P. A. E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer   +16 more
wiley   +1 more source

Preliminary question and stay of administrative procedure

, 2018
Magistrsko diplomsko delo »Predhodno vprašanje in prekinitev upravnega postopka« obravnava procesna instituta upravnega postopka, in sicer predhodno vprašanje ter prekinitev postopka.
Pršo, Sara
core   +1 more source

Irish treebanking and parsing: a preliminary evaluation [PDF]

, 2012
Language resources are essential for linguistic research and the development of NLP applications. Low- density languages, such as Irish, therefore lack significant research in this area.
Lynn, Teresa, Foster, Jennifer, Cetinoglu, Ozlem, Dras, Mark, van Genabith, Josef, Uí Dhonnchadha, Elaine   +5 more
core  

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Sense-based Blind Relevance Feedback for Question Answering

, 2004
This paper addresses the problem of enhancing document retrieval under the specific restrictions posed by the Question Answering scenario. In particular, given an input question, we aim at defining a reliable method for expand ing its keywords with ...
Negri, Matteo
core