Results 41 to 50 of about 3,507,474 (289)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

ICT-DCU question answering task at NTCIR-6 [PDF]

open access: yes, 2007
This paper describes details of our participation in the NTCIR-6 Chinese-to-Chinese Question Answering task. We use the “retrieval plus extraction approach” to get answers for questions.
Zhang, Sen   +2 more
core   +2 more sources

La gouvernementalité algorithmique : radicalisation et stratégie immunitaire du capitalisme et du néolibéralisme ? [PDF]

open access: yesLa Deleuziana, 2016
This article is a set of reflections on the question: ‘what is completely new in algorithmic governmentality compared to capitalism and neoliberalism?’ The following text is thus some preliminary, temporary and definitively uncertain intuitions in ...
Antoinette Rouvroy
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

LCC-DCU C-C question answering task at NTCIR-5 [PDF]

open access: yes, 2005
This paper describes the work for our participation in the NTCIR-5 Chinese to Chinese Question Answering task. Our strategy is based on the “Retrieval plus Extraction” approach.
Jones, Gareth J.F., Wang, Bin
core   +2 more sources

Un asunto sin resolver: la cuestionada constitucionalidad de la irrecurribilidad ante la jurisdicción contenciosoadministrativa de las resoluciones de la Comisión Arbitral(1

open access: yesRevista Vasca de Administración Pública, 2008
Lodged a preliminary question on the constitutionality of the legal system established for the Decisions adopted by the Arbitration Commission, because the petitioner had abbandoned the contentious-administrative action, the Constitutional Court stated ...
EDORTA COBREROS MENDAZONA
doaj   +1 more source

Preliminary Pages / Páginas preliminares

open access: yes, 2013
Preliminary Pages / Páginas ...
Preliminary Pages, BSJ
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Commoning in der Standortsuche für ein Endlager?: Neue Wege kollektiven Handelns

open access: yesTATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2022
This article addresses the question of whether Elinor Ostrom’s research on commons governance can open up new interpretive possibilities with regard to current institutionalization processes in the site selection process and for dealing with high-level ...
Dörte Themann
doaj   +1 more source

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