Results 51 to 60 of about 3,507,474 (289)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

European Court of Justice and its Impact on the European Integration

Czech Journal of International Relations, 2005
This text deals with channels of communication, which were used by the EU judiciary to influence the development of the European integration, and with reasons for the respect for EU judicial activism from the member states and other EU institutions ...
Ivo Šlosarčík
doaj  

Zero temperature properties of mesons in a vector meson extended linear sigma model

EPJ Web of Conferences, 2011
A three flavor linear sigma model with vector and axial-vector mesons is discussed. Preliminary results concerning on the symmetry breaking pattern, the question of parameterization, as well as the resulting meson masses are presented.
Giacosa F., Wolf G., Kovács P., Parganlija D.   +3 more
doaj   +1 more source

Developing a Why–How Question Answering system on community web boards with a causality graph including procedural knowledge

Information Processing in Agriculture, 2016
The research aims to develop an automatic Question Answering system, in particular Why and How questions, on community web-boards to support ordinary people in preliminary diagnosis and problem solving, such as plant disease problems.
C. Pechsiri, R. Piriyakul
doaj   +1 more source

Towards Collaborative Question Answering: A Preliminary Study

CoRR, 2022
Knowledge and expertise in the real-world can be disjointedly owned. To solve a complex question, collaboration among experts is often called for. In this paper, we propose CollabQA, a novel QA task in which several expert agents coordinated by a moderator work together to answer questions that cannot be answered with any single agent alone.
Xiangkun Hu, Hang Yan 0001, Qipeng Guo, Xipeng Qiu, Weinan Zhang 0001, Zheng Zhang 0001   +5 more
openaire   +3 more sources

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

A preliminary look at negative constructions in South African Sign Language: question-Answer clauses

Stellenbosch Papers in Linguistics, 2017
How negation is expressed by means of manual and/or non-manual markers has been described in a wide range of sign languages. This work has suggested a split between sign languages requiring a manual negative element in negative clauses (manual dominant ...
Huddlestone, Kate
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Development and preliminary results on the feasibility of a renal diet specific question prompt sheet for use in nephrology clinics

BMC Nephrology, 2019
Background Adherence to the diet prescription for chronic kidney disease is suboptimal. Interventions to improve dietary adherence suggest that improving communication between the patient and the health professional is fundamental to improving outcomes ...
Kelly Lambert, Tsz Kwan Lau, Sarah Davison, Holly Mitchell, Alex Harman, Mandy Carrie   +5 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source