Results 91 to 100 of about 7,097,764 (236)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Practical Considerations Regarding the Preliminary Ruling Procedure Under Article 177 of the EEC Treaty [PDF]

, 1986
Part I of this Article considers the role played by the preliminary ruling procedure in the context of the Community legal system as a whole. Part II discusses the types of questions that may be appropriately referred to the Court for preliminary ruling.
Dauses, Manfred A.
core  

Preliminary Pages

, 2016
Preliminary ...
Pages, Preliminary
core   +2 more sources

Preliminary hearing handbook (The Rutter Group, criminal practice series).

, 2023
Preliminary hearing handbook provides a comprehensive review of the law and procedure encountered in preliminary hearing courtrooms in California. The handbook's structure and readily accessible content enable bench officers, prosecutors, and defense ...
Bensinger, Kerry,
core  

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Performance Comparison of Reverse-Engineered and Newly Designed Impellers in a Centrifugal Pump Operating in Pump and Turbine Modes

Fluids
This study compares the hydraulic performance of two centrifugal-pump impellers operating in pump and pump-as-turbine (PAT) modes: a reverse-engineered impeller obtained from a commercial pump by 3D scanning and an impeller developed through a ...
Sebastian Atarihuana, José Erazo, Guillermo Barragán, Mateo Narváez, Héctor Calvopiña, Víctor Hidalgo   +5 more
doaj   +1 more source

The Limits of the Protection of the Rule of Law in Preliminary Reference Procedures

Európai Tükör
The principle of effective judicial protection has evolved from a general principle of EU law into a principle of constitutional nature linked to the rule of law. The preliminary ruling procedure of the EU has played an essential role in this development, as the ECJ has adapted for the purpose of the protection of judicial independence, the rules on ...
openaire   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

From Executive Design to Heritage Site: Preliminary Development of an Application for Integrating Information on the State of Conservation Within an HBIM Model

Buildings
In conservation work on historic built heritage, the transition from executive design to the worksite often requires the verification, integration and updating of information acquired during the design phase.
Carlo Battini, Margherita Valentini, Rita Vecchiattini   +2 more
doaj   +1 more source