Results 71 to 80 of about 225,202 (254)

Trust Issues? Article 99 RoP Reasoned Orders in the Preliminary Reference Procedure

Erasmus Law Review
This article explores reasoned orders issued by the Court of Justice (the Court) to reply to preliminary references of the national courts in the procedure for a preliminary ruling of Article 267 TFEU. Reasoned orders allow the Court to reply in a swiftly manner to preliminary references that raise no doubts.
MOBILE - Center of Excellence for Global Mobility Law, Lucía López Zurita   +1 more
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Organisation of the internal functioning of the State's judiciary and the principle of subsidiarity and respect for Member States' competences.

Eastern European Journal of Transnational Relations
The article examines the division of competences between the European Union and its Member States in the light of the judgment of the Court of Justice of the European Union (CJEU) in joined cases C 748/19 to C 754/19. The analysis focuses on two closely
Marcin Sokołowski
doaj   +1 more source

Position of the arbitration tribunals in the EU legal order [PDF]

Strani pravni život, 2018
The EU Treaties provide that only courts and tribunals from Member States may raise a question on the interpretation and validity of EU law to the Court of Justice of the EU (267 EU). The reference for a preliminary ruling is an important procedure whose
Vukadinović-Marković Jelena
doaj  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Equitable access to a personalized treatment with the OncoCREAN national strategy in pediatric patients with acute lymphoblastic leukemia from the Mexican Social Security Institute

Frontiers in Oncology
IntroductionThe Mexican Social Security Institute (IMSS) was created in 1943 as the main public institution in Mexico.MethodsIn 2020, the OncoCREAN (Centros de Referencia Estatal para la Atención del Niño y de la Niña con Cáncer) strategy was ...
Enrique Lopez Aguilar, Angeles Del Campo Martinez, Ana Rioscovian Soto, Karen Ayala-Contreras, Marta Zapata-Tarrés, Miguel Enrique Cuéllar Mendoza, Yadira Betanzos Cabrera, Regina Zevada-Mosti, Sheyla Payán Romo, Oscar Omar Esquer Cota, Pamela Zazueta Mérida, Susana Elizabeth Anaya Aguirre, Emmanuel Rolando Rodríguez Cedeño, Maria De Lourdes Gutiérrez Rivera, Jorge Alfonso Martín Trejo, Elvia Yaroslab Mayorga Castillo, Carolina Contreras Camacho, Elio Aaron Reyes Espinoza, Norma Eryca Alatoma Medina, Hector Manuel Tiznado García, Christian Santillán Ávila, Jose Maria Sepúlveda Núñez, Sadya Fuerte Olvera, Lizeth Rodríguez Brindis, Jose Alvaro Parra Salazar, Lilia Adela García Stivalet, Lizette Bojórquez Steffani, Roberto Abraham Betancourt Ortiz, Aurora Treviño, Julio Mercado Castruita, Rocio Aburto Mejia, Adrian Jimenez Salinas, Francisco Javier Valdivia Ibarra, Fabiana Maribel Zepeda Arias, Ana Leticia Figueroa Rosas, Desiree Sagarnaga Durante, Fatima Borrego Perez, Jorge Humberto Urbina Ochoa, Gustavo Ignacio Prieto Torres, Jose De Jesus Chavez Martenez, Juan Gilberto Perez Soltero, Guillermo Careaga Reyna, Ma. Teresa Cristina Ramos Hernandez, Rocio Cardenas Navarrete, Elsa Fabiola Gonzalez Rosas, Adolfo Pineda Gordillo, Cecilia Ochoa-Drucker, Enrique López Facio, Mirna Guadalupe Rios Osuna, Claudia Selene Portillo Zavala, Sergio Ruben Cobo Ovando, A. B. Aguilar Román, Brenda Chávez Liñán, Benjamin Arroyo Acosta, Luis E. Bernabe-Gaspar, A. B. Rivera Ramírez, D. A. Malváez Estrada, E. Ulloa Salaices, V. P. Silva Delfín, G. González Villarreal, M. Estolando Ayón, Aaron Muñoz Flores, E. F. Ortiz de la O, H. J. Ortiz Trujillo, José Luis Moreno Domínguez, Miguel Lopez Suastegui, L. Gallegos Cruz, Celida Duque-Molina   +67 more
doaj   +1 more source

Electrocochleographic recording in Asian adults: Preliminary normative data and demographic analyses

Journal of Otology, 2017
Objective: Electrocochleography (ECochG) is valuable to diagnose Meniere's disease objectively. The aim of the present study was to provide preliminary normative data for ECochG among Asian adults.
Mohd Normani Zakaria, Nik Adilah Nik Othman, Zalilah Musa   +2 more
doaj   +1 more source

The Limits of the Protection of the Rule of Law in Preliminary Reference Procedures

Európai Tükör
The principle of effective judicial protection has evolved from a general principle of EU law into a principle of constitutional nature linked to the rule of law. The preliminary ruling procedure of the EU has played an essential role in this development, as the ECJ has adapted for the purpose of the protection of judicial independence, the rules on ...
openaire   +1 more source