Results 81 to 90 of about 224,919 (256)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Organisation of the internal functioning of the State's judiciary and the principle of subsidiarity and respect for Member States' competences.

Eastern European Journal of Transnational Relations
The article examines the division of competences between the European Union and its Member States in the light of the judgment of the Court of Justice of the European Union (CJEU) in joined cases C 748/19 to C 754/19. The analysis focuses on two closely
Marcin Sokołowski
doaj   +1 more source

Position of the arbitration tribunals in the EU legal order [PDF]

Strani pravni život, 2018
The EU Treaties provide that only courts and tribunals from Member States may raise a question on the interpretation and validity of EU law to the Court of Justice of the EU (267 EU). The reference for a preliminary ruling is an important procedure whose
Vukadinović-Marković Jelena
doaj  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Equitable access to a personalized treatment with the OncoCREAN national strategy in pediatric patients with acute lymphoblastic leukemia from the Mexican Social Security Institute

Frontiers in Oncology
IntroductionThe Mexican Social Security Institute (IMSS) was created in 1943 as the main public institution in Mexico.MethodsIn 2020, the OncoCREAN (Centros de Referencia Estatal para la Atención del Niño y de la Niña con Cáncer) strategy was ...
Enrique Lopez Aguilar, Angeles Del Campo Martinez, Ana Rioscovian Soto, Karen Ayala-Contreras, Marta Zapata-Tarrés, Miguel Enrique Cuéllar Mendoza, Yadira Betanzos Cabrera, Regina Zevada-Mosti, Sheyla Payán Romo, Oscar Omar Esquer Cota, Pamela Zazueta Mérida, Susana Elizabeth Anaya Aguirre, Emmanuel Rolando Rodríguez Cedeño, Maria De Lourdes Gutiérrez Rivera, Jorge Alfonso Martín Trejo, Elvia Yaroslab Mayorga Castillo, Carolina Contreras Camacho, Elio Aaron Reyes Espinoza, Norma Eryca Alatoma Medina, Hector Manuel Tiznado García, Christian Santillán Ávila, Jose Maria Sepúlveda Núñez, Sadya Fuerte Olvera, Lizeth Rodríguez Brindis, Jose Alvaro Parra Salazar, Lilia Adela García Stivalet, Lizette Bojórquez Steffani, Roberto Abraham Betancourt Ortiz, Aurora Treviño, Julio Mercado Castruita, Rocio Aburto Mejia, Adrian Jimenez Salinas, Francisco Javier Valdivia Ibarra, Fabiana Maribel Zepeda Arias, Ana Leticia Figueroa Rosas, Desiree Sagarnaga Durante, Fatima Borrego Perez, Jorge Humberto Urbina Ochoa, Gustavo Ignacio Prieto Torres, Jose De Jesus Chavez Martenez, Juan Gilberto Perez Soltero, Guillermo Careaga Reyna, Ma. Teresa Cristina Ramos Hernandez, Rocio Cardenas Navarrete, Elsa Fabiola Gonzalez Rosas, Adolfo Pineda Gordillo, Cecilia Ochoa-Drucker, Enrique López Facio, Mirna Guadalupe Rios Osuna, Claudia Selene Portillo Zavala, Sergio Ruben Cobo Ovando, A. B. Aguilar Román, Brenda Chávez Liñán, Benjamin Arroyo Acosta, Luis E. Bernabe-Gaspar, A. B. Rivera Ramírez, D. A. Malváez Estrada, E. Ulloa Salaices, V. P. Silva Delfín, G. González Villarreal, M. Estolando Ayón, Aaron Muñoz Flores, E. F. Ortiz de la O, H. J. Ortiz Trujillo, José Luis Moreno Domínguez, Miguel Lopez Suastegui, L. Gallegos Cruz, Celida Duque-Molina   +67 more
doaj   +1 more source

Electrocochleographic recording in Asian adults: Preliminary normative data and demographic analyses

Journal of Otology, 2017
Objective: Electrocochleography (ECochG) is valuable to diagnose Meniere's disease objectively. The aim of the present study was to provide preliminary normative data for ECochG among Asian adults.
Mohd Normani Zakaria, Nik Adilah Nik Othman, Zalilah Musa   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Limits of the Protection of the Rule of Law in Preliminary Reference Procedures

Európai Tükör
The principle of effective judicial protection has evolved from a general principle of EU law into a principle of constitutional nature linked to the rule of law. The preliminary ruling procedure of the EU has played an essential role in this development, as the ECJ has adapted for the purpose of the protection of judicial independence, the rules on ...
openaire   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source