Results 51 to 60 of about 1,272,715 (288)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation [PDF]

Hemijska Industrija, 2015
Antimicrobial activity of Usnea barbata especially against bacteria involved in pathogenesis of various skin conditions has been well documented in literature.
Žugić Ana R., Lukić Milica Z., Tasić-Kostov Marija Z., Tadić Vanja M., Arsić Ivana A., Mišić Dušan R., Petrović Slobodan D., Savić Snežana D.   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ANOMALIES OF THE LEGAL STATUS OF THE INQUIRY BODIES

Правовое государство: теория и практика, 2023
A feature of the legal status of the inquiry bodies is that they have no uniform procedural status: some have full powers (for the conduct of preliminary investigations in the form of initial inquiries, urgent investigative actions and execution of ...
DIKAREV Ilya Stepanovich
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection

Frontiers in Medicine, 2020
Objectives: To report the management of three consecutive patients with relapsing Staphylococcus aureus prosthetic knee infection (PKI) for whom explantation was not feasible who received a phage therapy during a “Debridement Antibiotics and Implant ...
Tristan Ferry, Tristan Ferry, Tristan Ferry, Tristan Ferry, Camille Kolenda, Camille Kolenda, Camille Kolenda, Camille Kolenda, Cécile Batailler, Cécile Batailler, Cécile Batailler, Claude-Alexandre Gustave, Claude-Alexandre Gustave, Claude-Alexandre Gustave, Claude-Alexandre Gustave, Sébastien Lustig, Sébastien Lustig, Sébastien Lustig, Matthieu Malatray, Matthieu Malatray, Cindy Fevre, Jérôme Josse, Jérôme Josse, Jérôme Josse, Jérôme Josse, Charlotte Petitjean, Christian Chidiac, Christian Chidiac, Christian Chidiac, Christian Chidiac, Gilles Leboucher, Frédéric Laurent, Frédéric Laurent, Frédéric Laurent, Frédéric Laurent   +34 more
doaj   +1 more source

‘“Grow Up!”: Rethinking the Preliminary Reference Procedure from the Perspective of Maturity’

LSE Law Review, 2021
The clash between the German Constitutional Court and the CJEU in May 2020 over economic policy highlights the growing tension between the EU and the courts of last instance in Member States. This article argues that such tensions demand a legal order which respects national judicial hierarchies, and thereby becoming mature.
openaire   +1 more source

Criminal procedures, preliminary references and judicial independence: A balancing act? Case C-564/19 IS

Maastricht Journal of European and Comparative Law, 2022
In Case C-564/19 IS, the Court of Justice of the European Union delivered a judgement on two significant issues of EU law. First, it clarified the obligations of Member States under Directive 2010/64/EU on the right to interpretation and translation in criminal proceedings regarding the provision of linguistic assistance during the criminal procedure ...
Ágoston Mohay, István Szijártó
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Simplified Approach for the Seismic Loss Assessment of RC Buildings at Urban Scale: The Case Study of Potenza (Italy)

Buildings, 2021
Comprehensive methodologies based on a fully probabilistic approach (i.e., the performance-based earthquake engineering approach, PBEE), represent a refined and accurate tool for the seismic performance assessment of structures. However, those procedures
Amedeo Flora, Donatello Cardone, Marco Vona, Giuseppe Perrone   +3 more
doaj   +1 more source