Results 21 to 30 of about 2,215,308 (245)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Fundamental Rights Complaints in the Preliminary Reference Procedure
, 2023 The procedure for a preliminary ruling is central in the ‘complete system of protection’ offered by the Union to its citizens. Since Article 263 TFEU grants only a very reduced standing to ‘non-privileged applicants’, Article 267 TFEU became the main way for individuals to bring their claims against the EU before the European Court of Justice.
MOBILE - Center of Excellence for Global Mobility Law +1 more
openaire +2 more sources
Preliminary results from a simulation of quenched QCD with overlap fermions on a large lattice
, 2003 We simulate quenched QCD with the overlap Dirac operator. We work with the Wilson gauge action at beta=6 on an 18^3x64 lattice. We calculate quark propagators for a single source point and quark mass ranging from am_q=0.03 to 0.75.
C. Hoelbling +26 more
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Very preliminary reference Moon model
Physics of the Earth and Planetary Interiors, 2011 Abstract The deep structure of the Moon is a missing piece to understand the formation and evolution of the Earth–Moon system. Despite the great amount of information brought by the Apollo passive seismic experiment (ALSEP), the lunar structure below deep moonquakes, which occur around 900 km depth, remains largely unknown.
Garcia, Raphaël +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2017 We describe the preliminary optimized layout for a partially optimized concept of an optical-8m class VLT-like 2x2 segmented camera where each channel is assisted by an equivalent of an MCAO system where the ground layer correction is commonly employed ...
Bergomi, Maria +12 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Toward an Ab-initio Description of Quasiparticle Properties [PDF]
, 2009 Preliminary ab-initio applications of many-body Green's functions theory to the ground state of He-4 suggest that high accuracy can be achieved in the so-called Faddeev-random-phase-approximation method.
Barbieri, C.
core +1 more source
Accessing directly the strange quark content of the proton at HERA [PDF]
, 1995 We investigate a double-spin asymmetry for the semi-inclusive $\Lambda$ hyperon production in the longitudinally deep inelastic lepton-proton scattering, the sign of which can provide us with important information about the strange quark helicity ...
Abe +31 more
core +3 more sources