Results 111 to 120 of about 284,274 (307)

¿Fin del derecho a indemnización por cese del personal laboral interino al servicio de la administración? la STS (Social) de 13 de marzo de 2019

open access: yesRevista Vasca de Administración Pública, 2019
The notorious case Diego Porras opened a path to an automatic right to severance payment on termination of employment for the temporary staff in the Administrations.
José Cabrera Rodríguez
doaj   +1 more source

¿Quién ha de pagar el incumplimiento del derecho de la Unión, el Estado o las Comunidades Autónomas? A propósito de algunos aspectos de interés del Informe del Consejo de Estado español de 15 de diciembre de 2010 [PDF]

open access: yesRevista d'Estudis Autonòmics i Federals, 2012
This paper analyses the different contexts in which the infringement of European law by Member States generates economic liabilities. The starting point is the distinction between the EU law-making powers and law-executing powers, which are conferred to ...
Miguel Azpitarte Sánchez
doaj  

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

open access: yesAdvanced Science, EarlyView.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi   +14 more
wiley   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

open access: yesAdvanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang   +12 more
wiley   +1 more source

A View from the Court of Justice. Some Considerations About the Transfer of Competence for Preliminary Rulings to the General Court: The Functioning of the Guichet Unique and a Brief Review After Nine Months of Implementation of the Reform

open access: yesEuropean Papers
(Series Information) European Papers - A Journal on Law and Integration, 2025 10(3), 877-888 | Article | (Table of Contents) 1. Introduction. – 2. The Guichet Unique Mechanism: Practical functioning and scope of examination. – 3.
Leila Rezki
doaj   +1 more source

Learnable Diffusion Framework for Mouse V1 Neural Decoding

open access: yesAdvanced Science, EarlyView.
We introduce Sensorium‐Viz, a diffusion‐based framework for reconstructing high‐fidelity visual stimuli from mouse primary visual cortex activity. By integrating a novel spatial embedding module with a Diffusion Transformer (DiT) and a synthetic‐response augmentation strategy, our model outperforms state‐of‐the‐art fMRI‐based baselines, enabling robust
Kaiwen Deng   +2 more
wiley   +1 more source

The Questions That Never Came: How National Judges Use Their Discretion in the Preliminary Ruling Procedure

open access: yesEuropean Journal of Empirical Legal Studies
While domestic judges ultimately decide whether to refer questions to the Court of Justice of the European Union (CJEU), little is known about how the idea to refer is introduced in national litigation or about the decision (not) to refer.
Isak Nilsson
doaj   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao   +11 more
wiley   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

open access: yesAdvanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo   +7 more
wiley   +1 more source

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