Results 191 to 200 of about 1,524,423 (296)

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

International legal responses to war crimes and genocide: a comparative analysis of Gaza, Ukraine, and Myanmar. [PDF]

Front Sociol
Khwaileh KM, Obeidat MA, Mohamed HSM.
europepmc   +1 more source

Scaffold RNA Reengineering for a Leakage‐Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics

Advanced Science, EarlyView.
Schematic illustration of the CALCas system, in which a conformational switch in the 3' terminal DNA extension of scaffold RNA (3'D‐SR) drives cascade‐activatable Cas12a cleavage while suppressing leakage. ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid ...
Xingrong Li, Honghua Hu, Xinli Jiang, Xuhuai Fu, Lin Hu, Qinghua Wu, Jiatong Chai, Diangeng Li, Jinhong Guo, Zhiqiang Li, Yi Li, Yirong Li   +11 more
wiley   +1 more source

The value of mNGS in the diagnosis of central nervous system infections in immunodeficient hosts with decompensated cirrhosis complicated by <i>Listeria encephalitis</i>: Case Report. [PDF]

Front Med (Lausanne)
Cao L, Zhao Y, Wang R, Liu Y, Luo L, Yan H, Li N.   +6 more
europepmc   +1 more source

CeO2‐Based Electrocatalysts for the Oxygen Evolution Reaction: Design, Dynamic Mechanisms, and Electrolyte Adaptability

Advanced Science, EarlyView.
This Review shows how cerium oxide helps water‐splitting catalysts work better and last longer. It explains how CeO2 tunes electronic structure, oxygen‐vacancy behavior, and surface reconstruction, while adapting to alkaline, acidic, and seawater conditions.
Zhen Cui, Ailing Song, Zirui Cui, Manman Duanmu, Zhipeng Ma, Hao Liu, Guangjie Shao, Xinyi Tan, Guoxiu Wang, Hao Tian   +9 more
wiley   +1 more source

Time- and Temperature-Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management. [PDF]

J Clin Lab Anal
Zhang L, Li M, Xie Z, Yao J, Cao Y, Chen L, Wang M.   +6 more
europepmc   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Co-evolutionary pathways of synthetic biology regulation: A comparative analysis of major countries and Korea's strategic legislation. [PDF]

J Microbiol
Kim H, Kwon Y, Kim HY, Lee J.
europepmc   +1 more source

An AI‐Driven Framework for Directed Self‐Assembly Toward Design‐Technology Co‐Optimization

Advanced Science, EarlyView.
An artificial intelligence (AI)‐driven closed‐loop framework integrates experiment, three‐dimensional physics‐based simulation, and template design for directed self‐assembly (DSA). Guided by experimental data, AI‐assisted calibration accelerates model optimization, supports morphology prediction, and identifies template windows.
Caiwei Shang, Yanting Xu, Yue Zhang, Yan Zhang, Jianfeng Li, Ming Li, Longlin Lei, Wenda Bao, Weixuan Zeng, Shisheng Xiong   +9 more
wiley   +1 more source

Do Unpaid Internships Breach Equality Law? [PDF]

Oxf J Leg Stud
Helme J.
europepmc   +1 more source