Results 161 to 170 of about 7,912 (256)

LLMs as Representation Generators for Gradient‐Free Scientific Optimization: A Case Study in Battery Fast Charging

open access: yesAdvanced Science, EarlyView.
Large language models serve as representation generators for gradient‐free scientific optimization. Two complementary approaches produce executable battery‐charging policies either directly or through LLM‐designed neural representations coupled to Bayesian optimization.
Ge Lei   +3 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

open access: yesAdvanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong   +15 more
wiley   +1 more source

Updating Disyllabic Word Lists for Italian Speech Audiometry. [PDF]

open access: yesLaryngoscope Investig Otolaryngol
Biondi L   +3 more
europepmc   +1 more source

Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials

open access: yesAdvanced Science, EarlyView.
Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo   +3 more
wiley   +1 more source

Non‐Covalent Reversibly Photoconvertible Fluorescent Tags for Wash‐Free Protein Labeling

open access: yesAdvanced Science, EarlyView.
FAST proteins combined with one or two fluorogens undergo reversible fluorescence switching or photoconversion through photoisomerization. At low fluorogen concentration and high light intensity, they act as negative or positive photoswitchers and photoconvertible tags, which are promising for discriminating FAST variants.
Mrinal Mandal   +12 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao   +7 more
wiley   +1 more source

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