Results 101 to 110 of about 179,014 (305)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

open access: yesAdvanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li   +12 more
wiley   +1 more source

Controversial Issues on the Requests and the Exceptions Invoked in the Preliminary Chamber Procedure - Jurisprudential Issues

open access: yesEIRP Proceedings, 2018
The present paper aims to analyze the stage of the preliminary chamber, phase of the criminal trial introduced by the Romanian legislator with the adoption of the New Criminal Procedure Code.
Sandra Gradinaru
doaj  

Toward a Procedure to Study Rule-Governed Choice: Preliminary Data

open access: yesThe Analysis of Verbal Behavior
Abstract The aim of this study was to model a situation that induced choice between following two incompatible rules, each associated with a different rate of reinforcement. In Experiment 1, eight undergraduate students were exposed to a two-component multiple schedule (training).
openaire   +2 more sources

Judicialization in international security: A theoretical concept and some preliminary evidence [PDF]

open access: yes
Many claim a process of judicialization of international dispute settlement procedures is taking place. In order to capture this ongoing process we introduce an analytical framework to assess the degree of judicialization of international dispute ...
Mondré, Aletta, Zangl, Bernhard
core  

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu   +7 more
wiley   +1 more source

THE BENEFITS OF A SPECIAL CRIMINAL PROCEEDINGS IN ABSENTIA [PDF]

open access: yesChallenges of the Knowledge Society, 2019
A criticism of the national legislator’s decision not to introduce a shortened hearing as a special criminal procedure in absentia, which would exclude the Preliminary Chamber and would leave the civil action unsolved.
Ioan-Paul CHIȘ
doaj  

Judging Rules, Ruling Judges [PDF]

open access: yes, 1998
Bureaucracy and complexity are not pejorative terms, but they are limiting terms, and it makes sense to examine the limitations that inhere in them.
Yeazell, Stephen C.
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao   +11 more
wiley   +1 more source

Procedural Aspects Regarding References for Preliminary Rulings

open access: yesRomanian Journal of European Affairs, 2008
The purpose of preliminary rulings, or the preliminary reference as it is known, can be traced directly to the need to secure uniformity in the Community legal order throughout the Member States. The procedure of preliminary rulings was mentioned for the first time by the Advocate General Joseph-Louis Lagrange 40 years ago in this Opinion in Bosch v de
openaire   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

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