Results 121 to 130 of about 179,014 (305)
New Roads Toward the Settlement of Federal Income, Estate, and Gift Tax Controversies [PDF]
, 1940 Surrey, Stanley S., Traynor, Roger John
core +2 more sources
EC Competition Law and Member State Courts [PDF]
, 1993 The main purpose of this paper is to critically analyze the “Notice on cooperation between national courts and the Commission in applying Articles 85 and 86 of the EEC Treaty” (the “Notice”), which the Commission of the European Community (the ...
Bourgeois, Jacques H.J.
core +1 more source
SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics
Advanced Science, EarlyView.ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao +11 more
wiley +1 more source
The Limitation of Intellectual Property in the Name of Competition [PDF]
, 2008 Intellectual property (“IP”) is often credited with providing an incentive for inventors to develop their creativity. Through IP protection, inventors can recoup their investment and make a profit.
Nihoul, Paul
core +1 more source
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
The Preliminary Ruling Procedure, Today: Revisiting Article 267 TFEU’s Constitutional Backbone
, 2023 As the title of the Special Issue suggests, its main purpose is to shed new light on the content, scope, extent, and limits of Article 267 TFEU in today’s Union and, in turn, on the nature of this procedure and the European Court of Justice (ECJ)’s role as a sui generis supranational court.
Daniele Gallo, Lorenzo Cecchetti
openaire +1 more source
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Foro, Revista de Derecho, 2017 El presente trabajo tiene por objeto analizar la Interpretación Prejudicial emitida por el Tribunal de Justicia de la Comunidad Andina dentro del Proceso 242-IP- 2015, la cual fue solicitada por la directora de Signos Distintivos de la Superintendencia ...
Gustavo García Brito
doaj
The Asymmetry Problem: Reflections on Calvin Massey’s Standing in State Courts, State Law, and Federal Review [PDF]
, 2017 This paper is based on remarks delivered at a symposium to honor my University of New Hampshire School of Law colleague Calvin Massey, who passed away in the fall of 2015. The paper discusses an asymmetry in federal standing law.
Greabe, John M.
core +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source