Results 121 to 130 of about 178,920 (285)

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

open access: yesAdvanced Science, EarlyView.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo   +3 more
wiley   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu   +7 more
wiley   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang   +17 more
wiley   +1 more source

Análisis de la interpretación prejudicial emitida por el Tribunal de Justicia de la Comunidad Andina dentro del Proceso 242-IP-2015 (Marca: TEXTURA SUPERFICIE "OLD PARR")

open access: yesForo, Revista de Derecho, 2017
El presente trabajo tiene por objeto analizar la Interpretación Prejudicial emitida por el Tribunal de Justicia de la Comunidad Andina dentro del Proceso 242-IP- 2015, la cual fue solicitada por la directora de Signos Distintivos de la Superintendencia ...
Gustavo García Brito
doaj  

Efficiency Measurements and Installation of a New Grating for the OSIRIS Spectrograph at Keck Observatory

open access: yes, 2014
OSIRIS is a near-infrared integral field spectrograph operating behind the adaptive optics system at W. M. Keck Observatory. While OSIRIS has been a scientifically productive instrument to date, its sensitivity has been limited by a grating efficiency ...
Adkins, Sean M.   +9 more
core   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen   +12 more
wiley   +1 more source

The Preliminary Ruling Procedure, Today: Revisiting Article 267 TFEU’s Constitutional Backbone

open access: yes, 2023
As the title of the Special Issue suggests, its main purpose is to shed new light on the content, scope, extent, and limits of Article 267 TFEU in today’s Union and, in turn, on the nature of this procedure and the European Court of Justice (ECJ)’s role as a sui generis supranational court.
Daniele Gallo, Lorenzo Cecchetti
openaire   +1 more source

Reference‐Guided Chromosome‐by‐Chromosome de novo Assembly at Scale Using Low‐Coverage High‐Fidelity Long‐Reads with HiFiCCL

open access: yesAdvanced Science, EarlyView.
HiFiCCL, as the first assembly framework specifically designed for low‐coverage high‐fidelity reads, improves the assembly quality of existing assemblers and also enhances downstream applications such as large structural variant (SV) detection (>10 000 bp), synteny analysis, pangenome graph construction, and graph‐based individual‐specific germline SVs
Zhongjun Jiang   +9 more
wiley   +1 more source

The EU System of Justice between Hierarchy and Dialog

open access: yesCzech Journal of International Relations, 2004
After the Aaccession to the European Union, the Czech courts have to meet requirements of the uniform enforcement of Community law. They should adopt methods of interpretation and procedures of application of law practiced within the European system of ...
Jiří Zemánek
doaj  

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