Results 161 to 170 of about 3,194,410 (281)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

End of life in Italy: ethical issues and medical-legal aspects of medically assisted suicide. [PDF]

Monash Bioeth Rev
Marisei M, Di Lorenzo P, Di Donna G, De Caro V, Policino F, Casella C.   +5 more
europepmc   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

The Impact of Generative AI Dependence on University Students' Creativity: The Mediating Role of Critical Thinking and the Moderating Role of Thinking Orientation. [PDF]

J Intell
Yuan F, Liu C, Yang J.
europepmc   +1 more source

The preliminary ruling procedure as part of a 'complete system of remedies': Does the obligation to seek a preliminary ruling ensure effective judicial protection of individuals?

, 2005
Access to court is essential for the protection of all rights of individuals. The same holds true for the rights individuals derive from Community law.
Briem, Hildur
core  

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Simultaneous endoscopic management of prostatic and seminal vesicle abscess using holmium laser enucleation of the prostate and seminal vesiculoscopy: a case series. [PDF]

J Med Case Rep
Zhang G, Wang J, Lu W, Zhao R.
europepmc   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Feasibility of On-Site CT-FFR Analysis in Ruling Out In-Stent Restenosis on Cardiac PCCT. [PDF]

J Cardiovasc Dev Dis
Ayx I, Waßmer F, Lichti L, Froelich MF, Buettner S, Papavassiliu T, Schoenberg SO, Germann T.   +7 more
europepmc   +1 more source

Strong Metal‐Support Interaction Driven Janus Reconstruction in PtRu Alloys for Low‐Temperature Hydrogen Storage

Advanced Science, EarlyView.
Strong metal‐support interactions (SMSI) drive the spontaneous segregation of RuPt alloy into Janus nanoparticles on CeO2, spatially partitioning Pt‐rich domains for H2 dissociation and Ru‐rich domains for toluene adsorption. This Janus nanocatalysts yield a turnover frequency of 10 906 h−1 for toluene hydrogenation at 50 °C, which is 6.7 times that of
Xingyu Zhang, Haiqiang Bai, Wenbin Li, You Wang, Yunhua Xu, Sai Zhang   +5 more
wiley   +1 more source