Results 121 to 130 of about 3,107,016 (263)

Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants

Advanced Science, EarlyView.
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr, Reuben Rideaux, Amaya J. Fox, David R. Lightfoot, Jason Tangen, Jason B. Mattingley, Shane E. Ehrhardt   +6 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Senate procedure committee - second report of 2011

, 2011
This report discusses potential changes to the functioning of the Senate. The report deals with: Operation of standing order 55(2) to (5) Consideration of private senators\u27 bills Procedures for dealing with formal motions Use of ...
Senate Standing Committee on Procedure
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Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

Advanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

N–O Dual Functional Group Transposition via Energy Transfer Photocatalysis

Advanced Science, EarlyView.
N–O dual functional group transposition (dFGT) enabled by the photocatalytic energy transfer (EnT) has been developed. This methodology is applicable to both activated and unactivated alkyl derivatives for dFGT, and it also successfully extended to N–N dFGT, demonstrating its general applicability.
Lei Bao, Xueyu Wang, Yang Zhou, Beibei Zhan, Xiaheng Zhang   +4 more
wiley   +1 more source

Should Lithuania be held liable for rarely requesting the Court of Justice of European Union to give a preliminary ruling?

, 2013
The purpose of this article is to decide whether Lithuania suitably exercises the duty arising from the Article 267 of Treaty on the Functioning of the European Union and probability of being liable for the breach of it.
Tamašauskaitė, Enrika, Greviškis, Justas   +1 more
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The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

The debiasing paradox: cognitive biases in judicial adjudication of valuation adjustment mechanisms across Chinese and American courts. [PDF]

Front Psychol
Gao Z.
europepmc   +1 more source

Decisions of courts of Republic of Latvia following preliminary rulings issued by the Court of Justice of the European Union

, 2018
Prejudiciālā nolēmuma institūts ir jau plaši pētīts, tomēr mazāk uzmanības tikusi pievērsta tā sekām, līdz ar to darba mērķis ir analizēt, kādas un cik saistošas ir prejudiciāla nolēmuma sekas uz dažādiem subjektiem - iesniedzējtiesu, pārējām Eiropas ...
Bogane, Ieva
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