Results 111 to 120 of about 56,336 (281)
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
The Area of Freedom, Security and Justice ten years on: Successes and future challenges under the Stockholm Programme. CEPS Paperbacks. June 2010 [PDF]
, 2010 This book celebrates the tenth anniversary of the Area of Freedom, Security and Justice (AFSJ) by bringing together the views of key practitioners and policy-makers who have played an outstanding role in thinking about and shaping EU policies on freedom,
Carrera, Sergio +2 more
core
Advanced Science, EarlyView.A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng +16 more
wiley +1 more source
Transfer of Undertakings, Insolvency Proceedings in the United Kingdom and Italy, and the European Court of Justice Case Law [PDF]
The current paper explores the application and revision process of the Ac-quired Rights Directive in the context of insolvency proceedings, focusing on the role of community and national (British and Italian) case law.
Giuseppe Sigillò Massara
core
Timing as Jurisdiction: Federal Civil Appeals in Context [PDF]
, 1984 The purpose of these few pages is to show that the calculus of appeal timing is inherently complex. If we are to continue the effort to capture the calculus in rules, the rules will be correspondingly complex.
Cooper, Edward H.
core +2 more sources
Advanced Science, EarlyView.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
Preliminary Rulings in The Civil Procedure
, 2015 This article explores the subject of preliminary rulings in the Chilean Civil Procedure. Namely, it is focused on those issues which, due to their logical and legal connection to the object of the process, must be decided by the same or a different Court, before the final and substantial judgement is made.
openaire +1 more source
Evolving Discretionary Practices of U.S Antidumping Activity [PDF]
Previous literature has discussed the procedural biases that exist in U.S. Department of Commerce (USDOC) dumping margin calculations. This paper examines the evolution of discretionary practices and their role in the rapid increase in average USDOC ...
Bruce A. Blonigen
core
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
Ten years of judicial cooperation [PDF]
, 2014 This paper intends to illustrate the respective roles and functions of the Court of Justice of the EU (CJEU) on the one hand, and the Maltese national courts on the other.
Clarke, Joseph Izzo +2 more
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