Results 241 to 250 of about 611,583 (274)

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Reducing prematurity-related neonatal mortality: a quality improvement project in Gandhi Memorial Hospital, Addis Ababa, Ethiopia. [PDF]

BMJ Open Qual
Wotango BY, Workneh WM, Abdana TD, Kidane H, Alemayehu M, Niku D, Alene B, Aragaw A, Belay Z, Adenew T, Hailu GT, Haile YG.   +11 more
europepmc   +1 more source

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

Case of Artificial Premature Labour [PDF]

S. S. Brame
openalex   +1 more source

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen, Yuan‐Yuan Wei, Jia‐Ying Kang, Da‐Wei Zhang, Jing‐Jing Ye, Xi‐Shi Sun, Mei Hong, Wen‐Ting Zhang, Hui‐Mei Wu, Zhen‐Xing Ding, Guang‐He Fei   +10 more
wiley   +1 more source

Music Therapy with Preterm Infants During Kangaroo Care: A Mixed-Methods Feasibility Study on Physiological and Electroencephalographic Parameters and Parental Perspectives. [PDF]

Children (Basel)
Kriechbaum AC, Csillag B, Wenzel C, Haslbeck FB.   +3 more
europepmc   +1 more source

Case of Premature Delivery, accompanied by Unusual Circumstances [PDF]

Tami Wallace
openalex   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Ureaplasma in neonatal gastric fluid contributing to bronchopulmonary dysplasia. [PDF]

BMC Pulm Med
Yan L, Deng H, Chen J, Liu Y, Duan S, Wang Z, Du L, Liang S, Xu L, Zhong D, Gao W, Zhang L.   +11 more
europepmc   +1 more source

Mitigating Strain Localization via Stabilized Phase Boundaries for Strengthening Multi‐Principal Element Alloys

Advanced Science, EarlyView.
Strain localization along phase or grain boundaries leads to crack initiation typical of alloys. In multi‐principal element alloys, the enamel‐like microstructure is stabilized by phase boundaries. This facilitates trans‐phase migration of semi‐atomic surfaces and provides sufficient plastic space for dislocation‐mediated deformation.
Jinliang Du, Shukuan Guo, Hangqi Feng, Weijie Li, Zhixin Huang, Zhongji Sun, Yunli Feng, Pei Wang, Ying Li   +8 more
wiley   +1 more source