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Rejuvenating premature aging [PDF]
Nature Medicine, 2008 Two commonly prescribed drugs, statins and aminobisphosphonates, may be helpful in combating the rare aging disorder, Hutchinson-Gilford progeria syndrome (pages 767–772).
Eran Meshorer, Yosef Gruenbaum
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Premature Aging in Fibromyalgia
Current Aging Science, 2015Chronic pain is highly prevalent in older adults, and until recently, was considered to be common but relatively "benign." Mounting evidence, however, suggests that some of the 116 million US adults who suffer from chronic pain are also at an increased risk for developing age-related diseases prematurely, suffering earlier cognitive and physical ...
Afton L. Hassett +2 more
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Dermatologic Clinics, 1987
The classic premature aging syndromes are rare disorders, all of which clinically differ a great deal from the normal aging process. None is well understood at the biochemical level, and no specific treatment exists for any of these syndromes. Genetic counseling, preventive measures in some instances, and symptomatic treatment are available.
Solange Beauregard, Barbara A. Gilchrest
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The classic premature aging syndromes are rare disorders, all of which clinically differ a great deal from the normal aging process. None is well understood at the biochemical level, and no specific treatment exists for any of these syndromes. Genetic counseling, preventive measures in some instances, and symptomatic treatment are available.
Solange Beauregard, Barbara A. Gilchrest
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Premature Aging and Alcoholism
International Journal of the Addictions, 1982The proposition is frequently put forth in the literature dealing with alcohol abuse that the process which underlies the cognitive impairment found in chronic alcoholics is premature aging of the central nervous system (Fitzhugh et al., 1965; Kish and Cheney, 1969; Goldstein and Shelly, 1971; Smith et al., 1971; Jones and Parsons, 1972; Kleinknecht ...
William R. Leber, Oscar A. Parsons
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Clinics in Dermatology, 1996
T he premature aging syndromes are rare disorders that mimic senescence. Interest in these syndromes has been great, in part because a more complete understanding of the pathophysiology of these syndromes may provide enhanced insight into the natural aging process.
Marti J. Rothe, Katherine Pesce
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T he premature aging syndromes are rare disorders that mimic senescence. Interest in these syndromes has been great, in part because a more complete understanding of the pathophysiology of these syndromes may provide enhanced insight into the natural aging process.
Marti J. Rothe, Katherine Pesce
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Etiological Factors and Premature Aging
JAMA, 1962AGING IS an interesting subject which is receiving increasing attention in many fields. There is an ever-enlarging body of information which indicates that many of the phenomena which were previously regarded as "natural" processes resulting from old age are actually due to specific disease processes.
John M. Knox +2 more
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2012
Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging.
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Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging.
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Molecular and Cellular Biochemistry, 2006
Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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Searching for clues to premature aging
Trends in Endocrinology & Metabolism, 2002Hutchinson-Gilford Progeria syndrome is a rare developmental disorder affecting most of the organ systems in a manner that mimics natural aging but at a markedly accelerated rate. A recent workshop at the NIH, aimed at further understanding the aging process, took an in-depth look at this complex syndrome.
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Science, 2018
Premature Aging Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. Larrieu et al. investigated the mechanisms by which a small molecule called remodelin improves the phenotype of HGPS cells (see the Focus by Wilson).
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Premature Aging Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. Larrieu et al. investigated the mechanisms by which a small molecule called remodelin improves the phenotype of HGPS cells (see the Focus by Wilson).
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