Results 141 to 150 of about 407,820 (365)

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

open access: yesAdvanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei   +15 more
wiley   +1 more source

Brain injury in premature infants may be related to abnormal colonization of early gut microbiome

open access: yesBMC Microbiology
Background Premature infants are more prone to brain injuries owing to incomplete nervous system development and poor adaptation outside the mother’s body.
Li Hou   +5 more
doaj   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

open access: yesAdvanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu   +7 more
wiley   +1 more source

Premature aging as a consequence of Mis-construction of tissues and organs during body development [PDF]

open access: yesarXiv, 2015
Hutchinson-Gilford Progeria syndrome, Werner syndrome, and Cockayne syndrome are three genetic disorders, in which the children have premature aging features. To understand the phenomenon of premature aging, the similarity of aging features in these syndromes to that in normal aging is investigated. Although these three syndromes have different genetic
arxiv  

Hormonal biomarkers and preterm birth: insights from a study of pregnant women in Lahore, Pakistan

open access: yesEndocrine Regulations
Objective. Reduced calciferol (vitamin D) levels in pregnant women have been associated with an increased risk to infant health. Progesterone sustains pregnancy and reduces the risk of premature birth through its metabolites affecting myometrial ...
Akram Sundas   +6 more
doaj   +1 more source

Preterm Birth’s Effects on Attachment

open access: yesCam & Sakura Medical Journal
The attachment established between the caregiver and the infant is a fundamental factor affecting mental health, starting from the prenatal period and developing during infancy.
Elif Yerlikaya Oral, Gül Karaçetin
doaj   +1 more source

Nourodevelopmental follow-up in high-risk infants: Review article [PDF]

open access: yes, 2015
Growing and developing are influenced by genetic, social and environmental factors and it's most important and initial phase step is formed of the early life of the fetus and infant.
Amiri, Mina.   +5 more
core   +1 more source

The contributions of genetics to premature birth [PDF]

open access: yesPediatric Research, 2019
David K. Stevenson   +5 more
openaire   +2 more sources

Integrating Spatial and Single‐Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development

open access: yesAdvanced Science, EarlyView.
Maternal pregestational diabetes mellitus (PGDM) induced metabolic stress in fetal mice pancreas, alongside significantly decreased insulin secretion, altered cell‐cell communication, and distinct changes in cellular niches. Abstract Maternal pregestational diabetes mellitus (PGDM) can lead to adverse fetal outcomes, including lasting impacts on ...
Yu Deng   +3 more
wiley   +1 more source

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