Results 151 to 160 of about 1,345,993 (362)

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen, Yuan‐Yuan Wei, Jia‐Ying Kang, Da‐Wei Zhang, Jing‐Jing Ye, Xi‐Shi Sun, Mei Hong, Wen‐Ting Zhang, Hui‐Mei Wu, Zhen‐Xing Ding, Guang‐He Fei   +10 more
wiley   +1 more source

PERCENTAGE OF DIALYZABLE ESTRADIOL-17β (DE2) FROM BIRTH TO ADULTHOOD AND IN SEXUAL PRECOCITY AND PREMATURE THELARCHE [PDF]

, 1974
Nezam Radfar, C. Richards, M Brych, Frederic M. Kenny   +3 more
openalex   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Development of Premature Twins with Dissimilar Birth Weight. I. Physical Development [PDF]

, 1972
A Janus-Kukulska, J. Kiepurska-Zdzienicka   +1 more
openalex   +1 more source

Mitigating Strain Localization via Stabilized Phase Boundaries for Strengthening Multi‐Principal Element Alloys

Advanced Science, EarlyView.
Strain localization along phase or grain boundaries leads to crack initiation typical of alloys. In multi‐principal element alloys, the enamel‐like microstructure is stabilized by phase boundaries. This facilitates trans‐phase migration of semi‐atomic surfaces and provides sufficient plastic space for dislocation‐mediated deformation.
Jinliang Du, Shukuan Guo, Hangqi Feng, Weijie Li, Zhixin Huang, Zhongji Sun, Yunli Feng, Pei Wang, Ying Li   +8 more
wiley   +1 more source

POSSIBILITIES OF PREDICTING PREMATURE BIRTH

Мать и дитя в Кузбассе
The conducted scientific research is devoted to the problem of finding predictors of preterm birth, because the available tests either have low information content or are an expensive technique. The purpose of the study.
Дмитрий Евгеньевич Беглов, Оксана Николаевна Новикова, Наталья Владимировна Артымук   +2 more
doaj  

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

The effectiveness of treatment-and-prophylactic sanitization measures for improvement outcomes of preterm labor

RUDN Journal of Medicine, 2012
In current article it is demonstrated that modernization tactics of preterm birth will assess potential infectious pregnant with the threat of premature birth, recovery eubioz by treatment-and-prophylactic sanitization measures.
M B Tamarkin, E V Zavadina, I N Kostin, A A Lukaev, E A Shishkin, N V Bolibok   +5 more
doaj  

Incompetent cervix: state-of-the-art [PDF]

РМЖ. Мать и дитя, 2019
O.V. Kuznetsova1, E.V. Zarubeeva2 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2N.V. Sklifosovsky Research Institute of First Aid, Moscow, Russian Federation This article provides a systematic analysis of ...
Kuznetsova O.V., E.V. Zarubeeva
doaj