Results 31 to 40 of about 179,410 (264)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Malocclusion and prematurity at birth.

Brazilian Journal of Implantology and Health Sciences, 2021
Newborns birth prematurely correspond to births with less than 37 weeks of gestation. There are some characteristics intrinsic to the premature ones that act in the Stomatognathic System, triggering the malocclusion. The objective of this article was to investigate the influences that prematurity at birth can generate in a dental environment, more ...
Cantuaria de Tarso, Marlus, Peixoto , João Cleber   +1 more
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Maternal Risk Factors Associated with Preterm Births among Pregnant Women in Mogadishu, Somalia

Children, 2022
Background: Premature birth impacts millions of newborns annually. Sixty percent of the world’s preterm births occur in Sub-Saharan Africa and South Asia.
Abdifetah Ibrahim Omar, Amina Dahir Mohamed, Mohamed Garad Farah, Ismail Abukar Mahad, Suban Abdullahi Mohamed, Abyan Hassan Dimbil, Nadifo Salad Mohamud, Fowziya Ahmed Abshir, Umayma Abdinasir Abdulkadir   +8 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Ultrasound Diagnostics of Premature Birth [PDF]

Саратовский научно-медицинский журнал, 2014
The purpose of the article is to analyze the data of native and foreign literature and to consider the modern aspects of ultrasound diagnostics of premature birth, and new additional criteria for early diagnostics and prediction of preterm delivery ...
Chekhonatskaya M.L., Vasilevich L.K., Petrosyan N.O., Kolesnikova E.A.   +3 more
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Determinants of Survival Time of Premature Neonates at Shambu General Hospital

Advances in Public Health, 2023
Background. Premature birth occurs before 37 completed weeks of gestation. It has a greater risk of developmental disabilities, health, and growth problems than full birth.
Olani Debelo
doaj   +1 more source

Hydration for prevention of premature births.

Nutricion hospitalaria, 2015
Introduction: Preterm births are one of the risk factors that increase infant morbidity and mortality worldwide. Primary prevention and treatment tools are known. Theoretically, hydration may reduce uterine contractility by increasing uterine blood flow and decrease the pituitary secretion of ADH and oxytocin. Objective: Find out if hydration in cases
M, Camacho Ávila, S, García Duarte, Mm, Ruíz Carmona, E, Hernández Sánchez   +3 more
openaire   +2 more sources