Results 191 to 200 of about 5,666,593 (242)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Effects of Premature Ventricular Complex Burden on Left Ventricular Global Longitudinal Strain in Patients without Structural Heart Disease. [PDF]

J Clin Med
Sukru A, Ozan AH, Furkan DM, Emin GM, Seyma A, Veysel O, Mustafa Y, Isıl U.   +7 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

A subtype of idiopathic ventricular fibrillation and its relevance to catheter ablation and genetic variants

HeartRhythm Case Reports, 2017
Takahiko Nishiyama, MD, Yoshiyasu Aizawa, MD, FHRS, Shogo Ito, MD, Yoshinori Katsumata, MD, Takehiro Kimura, MD, FHRS, Seiji Takatsuki, MD, FHRS, FESC   +5 more
doaj   +1 more source

Three-Day Monitoring of Adhesive Single-Lead Electrocardiogram Patch for Premature Ventricular Complex: Prospective Study for Diagnosis Validation and Evaluation of Burden Fluctuation. [PDF]

J Med Internet Res
Ahn HJ, Choi EK, Lee SR, Kwon S, Song HS, Lee YS, Oh S.   +6 more
europepmc   +1 more source

Prenatal air pollution exposure is associated with altered neurodevelopmental outcomes in early childhood

The Journal of Physiology, EarlyView.
Abstract figure legend This study examined the effect of modelled maternal air pollution exposure during gestation on neurodevelopment in a community cohort of 498 toddlers recruited from Greater London, UK. Higher 1st trimester exposure to particulate matter and nitrogen dioxide was associated with lower language scores at 18 months adjusting for ...
Alexandra F. Bonthrone, Brendan Bos, Ben Barratt, Hoi Ching Olina Pang, Sean Beevers, Andrew Chew, Shona Falconer, Joseph V. Hajnal, Frank J. Kelly, Chiara Nosarti, A. David Edwards, Serena J. Counsell   +11 more
wiley   +1 more source

Correction: Three-Day Monitoring of Adhesive Single-Lead Electrocardiogram Patch for Premature Ventricular Complex: Prospective Study for Diagnosis Validation and Evaluation of Burden Fluctuation. [PDF]

J Med Internet Res
Ahn HJ, Choi EK, Lee SR, Kwon S, Song HS, Lee YS, Oh S.   +6 more
europepmc   +1 more source

Panoramic voltage‐sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras

The Journal of Physiology, EarlyView.
Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary, Jan Lebert, Shai Dickman, Mason Manetta, Charles Gordon, Jan Christoph   +5 more
wiley   +1 more source