Results 121 to 130 of about 1,912,395 (308)

Severe skeletal fragility in SCN8A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract In this child with a phenotype compatible with the SCN8A gain‐of‐function spectrum, more than 20 bone fractures were documented. Together with previously reported cases, these observations raise the possibility that skeletal fragility may represent an underrecognized feature of the clinical spectrum associated with pathogenic SCN8A variants ...
Adélia Maria de Miranda Henriques‐Souza, Kette D. Valente   +1 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Prenatal–Postnatal Heavy Metal Exposure in Relation to Neurodevelopmental Disorder and ADHD: A Systematic Review

Diponegoro International Medical Journal
Introduction: Susceptibility to environmental insults during fetal brain development has been linked to an increased risk of neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD).
Gabriela Valencia Putri Husodho, Ichsan Marzuki Prasadah, Anatalya Diah Ayu Kumalasari, Talitha Aristawati Listiyanti, Rivaldo Heru Setiawan, Saekhol Bakri   +5 more
doaj   +1 more source

The effects of secondhand smoke exposure during adolescents on adult lung function [PDF]

, 2012
Mainstream cigarette smoke is known to causes decreases in lung function. This is a potential concern for those subjected to secondhand smoke. The purpose of this study was to compare the effects of secondhand smoke on young adults that either were or ...
Michalski, Meghan
core  

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Attitudes toward sodium valproate use, withdrawal, and counseling in people of reproductive potential: A scoping review

Epilepsia Open, EarlyView.
Abstract Regulatory restrictions and evolving clinical guidelines have aimed to reduce sodium valproate use in people of reproductive potential over the past decade due to its teratogenic risk. While clinical evidence and policy responses are well established, stakeholder perspectives remain less explored.
Katherine Wang, Sarah Loveday, Monica S. Cooper, Emma Macdonald‐Laurs   +3 more
wiley   +1 more source

Sex-Specific Associations between Prenatal Exposure to Di(2-ethylhexyl) Phthalate, Epigenetic Age Acceleration, and Susceptibility to Early Childhood Upper Respiratory Infections

Epigenomes
Di(2-ethylhexyl) phthalate (DEHP) is a common plasticizer that can affect immune system development and susceptibility to infection. Aging processes (measured as epigenetic age acceleration (EAA)) may mediate the immune-related effects of prenatal ...
Sarah M. Merrill, Nicole Letourneau, Gerald F. Giesbrecht, Karlie Edwards, Julia L. MacIsaac, Jonathan W. Martin, Amy M. MacDonald, David W. Kinniburgh, Michael S. Kobor, Deborah Dewey, Gillian England-Mason, The APrON Study Team   +11 more
doaj   +1 more source

Health and Economic Impacts of an Early Labor Induction Policy for High‐BMI Mothers

Health Economics, EarlyView.
ABSTRACT We expand the literature on marginal returns to birth interventions by studying a common intervention: early induction of labor for a growing share of pregnancies, high‐Body Mass Index (BMI) women. We exploit Danish guidelines which recommend routine induction at 7 days after the expected due date instead of 10–13 days after for mothers with a
Louis Freget, Maria Koch Gregersen
wiley   +1 more source

Health Risks From Mercury-Contaminated Fish: A Reassessment [PDF]

Several Congressional bills and a pending EPA regulation would significantly cut mercury emissions from power plants, so as to reduce mercury-related neurological effects among children.
Mader, Elizabeth A., Lutter, Randall
core