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Delayed Developmental Effects Following Prenatal Exposure to Drugs
Increasing evidence points to the possible risks of delayed effects upon prenatal exposure to chemicals; the evaluation of such effects may pose serious problems to clinicians, epidemiologists and toxicologists. In fact, several systems (e.g., nervous, excretory) show important developmental processes well after the organogenetic period, up to the ...
A, Mantovani, G, Calamandrei
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Delayed neurochemical effects of prenatal exposure to MeHg in the cerebellum of developing rats
Human fetuses and neonates are particularly vulnerable to methylmercury (MeHg)-induced brain damage and are sensitive even to low exposure levels. Previous work of our group evidence that prenatal exposure to MeHg causes cognitive and behavioral alterations and disrupt hippocampus signaling.
Luana, Heimfarth +6 more
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Of 25 mature female guinea pigs exposed transplacentally to diethylstilbestrol (DES) for more than 20 days before term, 8 showed abnormal changes in the genital tract (stimulation of the epithelium and stroma, cystic glandular hyperplasia of the endometrial glands near the junction of the upper endocervix and endometrium) and 9 showed severe changes ...
J, Davies, J, Lefkowitz
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The effects of histochrome on the severity of delayed effects of prenatal exposure to lead nitrate were studied in the rat brain. Exposure of pregnant rats to lead nitrate during activation of free radical oxidation reduced activity of NADH- and NADPH-dehydrogenases in cortical neurons of their 40-day-old progeny, reduced the number of neurons in a ...
B Ya, Ryzhavsky +2 more
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[Delayed effects of prenatal exposure to phenobarbital on intelligence--Phenemal].
Two double-blind studies were conducted on two independent samples of adult men prenatally exposed to phenobarbital and matched control samples using two different measures of general intelligence (WAIS and a draft board test (BPP)). The two studies included 33 and 81 exposed adult men respectively, and the two control groups included 52 and 101 ...
E L, Mortensen +3 more
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Effects of prenatal alcohol and marijuana exposure: Delayed maturation of visual evoked responses
Mark S. Scher +5 more
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Prenatal Exposure to Ethanol Disrupts Spatial Memory: Effect of the Training–Testing Delay Period
Physiology & Behavior, 1998The present study investigated how variations in the period of delay between training and testing in the Morris water maze task affect the use of spatial memory in adult rats that were prenatally exposed to ethanol. Previous results utilizing the Morris water maze task have shown that prenatal, or early postnatal, exposure to ethanol produces deficits ...
D B, Matthews, P E, Simson
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Delayed effect of prenatal exposure to hypoxia on the susceptibility of rats to electric seizures
Doklady Biological Sciences, 2015We studied the delayed effects of prenatal exposure to hypoxia on the susceptibility of rats to seizures. The later was estimated using graded electroshock. The experiments were performed in two groups of 1.5-year-old male Wistar rats. The experimental group consisted of the animals that were exposed to hypoxia on day 14 of prenatal development, and ...
D S, Kalinina +8 more
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