Results 111 to 120 of about 5,393,793 (388)

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

An educational tool to improve patient perceptions on the roles of an anesthesiologist and the importance of pre-anesthetic evaluation: A quality initiative study

The Indian Anaesthetists' Forum, 2020
Background: There is a huge deficit in patient knowledge about roles played by an anesthesiologist and about the relevance of a proper preanesthetic evaluation.
Smitha Elizabeth George, Grace Rebekah, Anita Shirley Joselyn   +2 more
doaj   +1 more source

Tourniquetless Total Knee Arthroplasty With Modern Perioperative Protocols Decreases Pain and Opioid Consumption in Women [PDF]

, 2018
Background This study examined whether a modern total knee arthroplasty (TKA) protocol without a tourniquet results in less patient-reported pain and in-hospital opioid consumption compared to TKA with a tourniquet.
Dilley, Julian E., Hood, Mark, Jr., Kheir, Michael M., Meneghini, R. Michael, Ziemba-Davis, Mary   +4 more
core   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

A pragmatic cluster randomised trial evaluating three implementation interventions [PDF]

, 2012
Background Implementation research is concerned with bridging the gap between evidence and practice through the study of methods to promote the uptake of research into routine practice.
AAGBI, AD Sutherland, AF Smith, ASA, C Stetler, CA Estabrooks, CB Stetler, Claire A Hawkes, Claire Allen, CM Godfrey, CR Ramsey, D Thompson, EA McGlynn, G Cumming, G Harvey, GJ Langley, Ian Bullock, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, Jackie Chandler, JM Grimshaw, JM Grimshaw, Jo Rycroft-Malone, JP Breuer, JT Crenshaw, Kate Seers, KE Thorpe, L Locock, L Wallin, LA Bero, Leo Strunin, LH Thomas, LM Schouten, LR Ferrari, M Brady, ME Seddon, MP Eccles, MT Kluger, N Jacobson, Nicola Crichton, P Hawe, R Baker, R Grol, R Hebballi, RCN/RCoA: Perioperative fasting in adults and children, S Dopson, S Dopson, S Fasting, S Hakkennes, S Leatherman, S Seymour, SC Goh, SM Nutley, T Greenhalgh, T McNulty, TA Sheldon, V Iles   +58 more
core   +2 more sources

Letter to the Editor: Effect of preoperative carbohydrate drink and postoperative chewing gum on postoperative nausea and vomiting in patients undergoing day care laparoscopic cholecystectomy: A randomized controlled trial [PDF]

, 2023
Bai Xue, Fu‐Shan Xue, Xinyue Li
openalex   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

The effect of preoperative stoma site marking on quality of life in patients undergoing ostomy surgery [PDF]

, 2008
The purpose of this study was to determine if preoperative stoma site marking by a Wound, Ostomy, Continence (WOC) nurse affects patient quality of life. This study used a descriptive design with a convenience sample of 25 ostomy patients.
Cantara, Susan L
core   +2 more sources

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source