Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
The effect of familiarization with preoperative care on anxiety and vital signs in the patient's cesarean section: A randomized controlled trial. [PDF]
Eur J Midwifery, 2021 Mostafayi M, Imani B, Zandi S, Jongi F.
europepmc +1 more source
Online Supports for Family Carers: Options & Experiences [PDF]
, 2016 One of the key developments of the late 20th and early 21st centuries is the development of the internet as an everyday tool used by the majority of citizens.
Care Alliance Ireland
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Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2
Advanced Science, EarlyView.Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang +15 more
wiley +1 more source
Journal of Education, Health and SportBackground: In elective plastic surgery, achieving safe outcomes and meeting patient expectations are paramount. The absence of complications remains the primary determinant of satisfaction, making the management of modifiable risk factors essential ...
Aneta Synakiewicz +8 more
doaj +1 more source
Patient-health care provider relationship during preoperative care in obstetric and gynecologic surgeries at Jimma Medical Center, Jimma, Ethiopia: patient's perspective. [PDF]
Perioper Med (Lond), 2022 Biyazin T +4 more
europepmc +1 more source
Disability and family carer policy - challenges and responses [PDF]
, 2017 A working definition of ‘disability’ is crucial to any research, policy development or service provision in the field. There are many definitions of disability (Iezzoni & Freedman, 2008), some directly contradicting others. These differences originate
Care Alliance Ireland
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MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer
Annals of Gastroenterological Surgery, EarlyView.Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li +5 more
wiley +1 more source
Preoperative Care Assessment of Need Scores Are Associated With Postoperative Mortality and Length of Stay in Veterans Undergoing Knee Replacement. [PDF]
Fed Pract, 2021 Kuo M +7 more
europepmc +1 more source
, 2016 It is widely understood that Family Carers are more likely to experience poor health (O’Sullivan, 2008), economic hardship (OECD, 2011), anxiety, stress, loneliness and isolation than the general population.
Care Alliance Ireland
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