Results 41 to 50 of about 249,078 (261)

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Development of a Nursing Practice Guideline for Pre and Post-Operative Care of Gastric Cancer Patients [PDF]

Healthcare Informatics Research, 2010
ObjectivesThe aim of this study was to develop nursing practice guidelines and algorithms for the pre- and postoperative care of gastric cancer patients.MethodsThe guidelines and algorithms were developed based on a literature review and subject-matter ...
Mi-Ok Park, Hyeoun-Ae Park
doaj   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Effect of exercise prehabilitation on days alive and out of hospital after cardiac surgery: a secondary analysis of the randomised PRE-habilitation for improving QUality of recovery after ELective cardiac surgery trial

BJA Open
Background: Postoperative healthcare utilisation and long-term survival are rarely evaluated after prehabilitation, limiting understanding of its sustained benefits.
Vivian N.M. Lau, Derek K.W. Yau, Floria F. Ng, Vicki W.S. Li, Kelly K.H. Wong, Christina H.L. Wong, Pik Yi Hou, Kwok Ming Ho, Anna Lee   +8 more
doaj   +1 more source

Preoperative evaluation of the feasibility of laparoscopic cholecystectomy [PDF]

Vojnosanitetski Pregled, 2005
Aim. To determine the possibility of preoperative evaluation of the feasibility of laparoscopic cholecystectomy based on the standard preoperative examinations and findings. Methods.
Jovanović Miodrag, Stanković Nebojša, Mirković Darko   +2 more
doaj   +1 more source

Brain‐Adhesive Bioelectronics With Shape‐Morphable and Biodegradable Properties for Stable Brain Signal Monitoring

Advanced Science, EarlyView.
A brain‐adhesive sensor (B‐Sensor) was developed by integrating a self‐healing biodegradable elastomer, a tissue‐adhesive hydrogel, and molybdenum electrodes. The B‐Sensor adheres to brain tissue, conforms to cortical curvatures, and maintains stable electrical performance over the intended period for reliable recording of spatiotemporal brain activity
Heewon Choi, Soeun Kim, Sumin Kim, Jaehyun Park, Soojung An, Sungjun Yoon, Mikyung Shin, Sangho Cho, Donghee Son   +8 more
wiley   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Sentimentos e fontes de apoio emocional de mulheres em pré-operatório de mastectomia em um hospital-escola [Feelings and sources of emotional support for women in pre-operative mastectomy in a teaching hospital]

Revista Enfermagem UERJ, 2015
O estudo objetivou identificar os sentimentos frente ao diagnóstico de câncer e a mastectomia e as fontes de apoio emocional. Estudo descritivo e de campo com abordagem qualitativa, realizado na Clínica Cirúrgica de um hospital-escola de referência no ...
Karla Tamyres Santos do Nascimento, Leila de Cássia Tavares da Fonsêca, Smalyanna Sgren da Costa Andrade, Kamila Nethielly Souza Leite, Tatiana Ferreira da Costa, Simone Helena dos Santos Oliveira   +5 more
doaj   +3 more sources

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source